Chaiyachati Barbara H, Gur Raquel E
The Children's Hospital of Philadelphia, Philadelphia, PA, United States of America; The University of Pennsylvania, Lifespan Brain Institute of Penn-Medicine and CHOP, Philadelphia, PA, United States of America; The Center for Pediatric Clinical Effectiveness and Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, United States of America; The Leonard Davis Institute, University of Pennsylvania, Philadelphia, PA, United States of America.
The Children's Hospital of Philadelphia, Philadelphia, PA, United States of America; The University of Pennsylvania, Lifespan Brain Institute of Penn-Medicine and CHOP, Philadelphia, PA, United States of America.
Pharmacol Biochem Behav. 2021 Jul;206:173195. doi: 10.1016/j.pbb.2021.173195. Epub 2021 May 5.
Childhood experiences impact long-term physical and behavioral health outcomes including potential risk for schizophrenia and psychosis. Negative experiences, such as child abuse and neglect, have been specifically associated with risk for schizophrenia and psychosis. This review provides a brief overview of child abuse and neglect, including its position within the larger field of trauma and adversity and its long term consequences. The link to schizophrenia is then explored. Principles of treatment and outcomes for schizophrenia with antecedent child abuse and neglect are then reviewed. Finally, next steps and points of prevention are highlighted.
童年经历会影响长期的身心健康结果，包括患精神分裂症和精神病的潜在风险。诸如虐待和忽视儿童等负面经历，已被明确与精神分裂症和精神病的风险相关联。本综述简要概述了虐待和忽视儿童的情况，包括其在更广泛的创伤和逆境领域中的地位及其长期后果。随后探讨了与精神分裂症的联系。接着回顾了有儿童期虐待和忽视史的精神分裂症的治疗原则和结果。最后，强调了后续步骤和预防要点。
