Department of Psychiatry, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.
Department of Psychological and Brain Sciences, University of Massachusetts Amherst, 135 Hicks Way/Tobin Hall, Amherst, MA 01003, USA.
Child Adolesc Psychiatr Clin N Am. 2020 Jan;29(1):115-129. doi: 10.1016/j.chc.2019.08.004. Epub 2019 Sep 23.
There is growing evidence to support the link between childhood trauma and psychosis. Childhood trauma increases the risk for psychosis and affects severity and type of psychotic symptoms, and frequency of comorbid conditions, including depression and substance use. Childhood trauma is linked to more severe functional impairment in individuals with psychosis. There is evidence to support gender differences in the influence of childhood trauma on the course of psychotic illnesses, appearing to be more profound in girls and women. Other biological markers that may explain the link between childhood trauma and psychosis include brain-derived neurotrophic factor and other inflammatory markers.
越来越多的证据支持儿童期创伤与精神病之间的关联。儿童期创伤会增加患精神病的风险，并影响精神病症状的严重程度和类型，以及合并症（包括抑郁和物质使用障碍）的发生频率。儿童期创伤与精神病患者更严重的功能障碍有关。有证据表明，儿童期创伤对精神病病程的影响存在性别差异，在女孩和女性中更为明显。其他可能解释儿童期创伤与精神病之间关联的生物学标志物包括脑源性神经营养因子和其他炎症标志物。
