Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, 100083, China.
College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Food Chem Toxicol. 2021 Jul;153:112251. doi: 10.1016/j.fct.2021.112251. Epub 2021 May 4.
Mycotoxins contaminate all types of food and feed, threatening human and animal health through food chain accumulation, producing various toxic effects. Increasing attention is being focused on the molecular mechanism of mycotoxin-induced toxicity in all kinds of in vivo and in vitro models. Epigenetic alterations, including DNA methylation, non-coding RNAs (ncRNAs), and protein post-translational modifications (PTMs), were identified as being involved in various types of mycotoxin-induced toxicity. In this review, the emphasis was on summarizing the epigenetic alterations induced by mycotoxin, including aflatoxin B1 (AFB1), ochratoxin A (OTA), zearalenone (ZEA), fumonisin B1 (FB1), and deoxynivalenol (DON). This review summarized and analyzed the roles of DNA methylation, ncRNAs, and protein PTMs after mycotoxin exposure based on recently published papers. Moreover, the main research methods and their deficiencies were determined, while some remedial suggestions are proposed. In summary, this review helps to understand better the epigenetic alterations induced by the non-genotoxic effects of mycotoxin.
真菌毒素污染所有类型的食物和饲料，通过食物链积累威胁人类和动物健康，产生各种毒性作用。越来越多的人关注各种体内和体外模型中真菌毒素诱导毒性的分子机制。表观遗传改变，包括 DNA 甲基化、非编码 RNA(ncRNAs)和蛋白质翻译后修饰(PTMs)，被认为与各种类型的真菌毒素诱导毒性有关。在这篇综述中，重点总结了真菌毒素(包括黄曲霉毒素 B1(AFB1)、赭曲霉毒素 A(OTA)、玉米赤霉烯酮(ZEA)、伏马菌素 B1(FB1)和脱氧雪腐镰刀菌烯醇(DON))诱导的表观遗传改变。本综述根据最近发表的论文，总结和分析了真菌毒素暴露后 DNA 甲基化、ncRNAs 和蛋白质 PTM 的作用，同时确定了主要的研究方法及其不足，并提出了一些补救建议。总之，本综述有助于更好地理解真菌毒素非遗传毒性诱导的表观遗传改变。
