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[对链霉素耐药的福氏志贺菌菌株毒力降低机制的研究]

[Study of the mechanism of reduction of the virulence in the Shigella flexneri strains resistant to streptomycin].

作者信息

Lycheva G A, Aleshkin G I

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1977 Sep(9):114-8.

PMID:339620
Abstract

Streptomycin-resistant mutations in donor strains of E. coli K12 Hfr AB 313 and AT-13 are not associated with the action of the strA-gene limiting the suppression. Shigella mutations str-r obtained by the method described in this paper also failed to limit the suppression. Changes in the virulence observed in transmission strA region from the str-r strains of E. coli and shigellae used in this work were not connected with mutations limiting the suppression (with competent mutations).

摘要

大肠杆菌K12 Hfr AB 313和AT - 13供体菌株中的链霉素抗性突变与限制抑制作用的strA基因的作用无关。通过本文所述方法获得的志贺氏菌str - r突变也未能限制抑制作用。在本研究中使用的从大肠杆菌和志贺氏菌的str - r菌株转移strA区域时观察到的毒力变化与限制抑制作用的突变(感受态突变)无关。

相似文献

1
[Study of the mechanism of reduction of the virulence in the Shigella flexneri strains resistant to streptomycin].[对链霉素耐药的福氏志贺菌菌株毒力降低机制的研究]
Zh Mikrobiol Epidemiol Immunobiol. 1977 Sep(9):114-8.
2
[Effect of the transmission of a different type of mutation in the strA locus on the virulence of Sh. flexneri].[福氏志贺菌strA位点不同类型突变的传递对其毒力的影响]
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[Mapping of mutations in genes of Flexner shigellae controlling the synthesis of certain ribosomal proteins and study of the effect of these mutations on bacterial virulence].[福氏志贺菌中控制某些核糖体蛋白合成的基因突变图谱绘制以及这些突变对细菌毒力影响的研究]
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On the metabolic characteristics of Shigella flexneri X Escherichia coli, devoid of ability for intracellular multiplication in epithelial cells. III. Oxygen uptake and dehydrogenase activity.
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Characterization of transferable plasmids from Shigella flexneri 2a that confer resistance to trimethoprim, streptomycin, and sulfonamides.福氏志贺菌2a中赋予对甲氧苄啶、链霉素和磺胺类药物耐药性的可转移质粒的特性分析。
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Reversion and transferability of nontransmissive R-factor.非传递性R因子的回复突变与转移性
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vacC, a virulence-associated chromosomal locus of Shigella flexneri, is homologous to tgt, a gene encoding tRNA-guanine transglycosylase (Tgt) of Escherichia coli K-12.志贺氏菌属弗氏志贺菌的毒力相关染色体位点vacC与大肠杆菌K-12的编码tRNA-鸟嘌呤转糖基酶(Tgt)的基因tgt同源。
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