[对链霉素耐药的福氏志贺菌菌株毒力降低机制的研究]
[Study of the mechanism of reduction of the virulence in the Shigella flexneri strains resistant to streptomycin].
作者信息
Lycheva G A, Aleshkin G I
出版信息
Zh Mikrobiol Epidemiol Immunobiol. 1977 Sep(9):114-8.
PMID:339620
Abstract
Streptomycin-resistant mutations in donor strains of E. coli K12 Hfr AB 313 and AT-13 are not associated with the action of the strA-gene limiting the suppression. Shigella mutations str-r obtained by the method described in this paper also failed to limit the suppression. Changes in the virulence observed in transmission strA region from the str-r strains of E. coli and shigellae used in this work were not connected with mutations limiting the suppression (with competent mutations).
摘要
大肠杆菌K12 Hfr AB 313和AT - 13供体菌株中的链霉素抗性突变与限制抑制作用的strA基因的作用无关。通过本文所述方法获得的志贺氏菌str - r突变也未能限制抑制作用。在本研究中使用的从大肠杆菌和志贺氏菌的str - r菌株转移strA区域时观察到的毒力变化与限制抑制作用的突变（感受态突变）无关。
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