Department of Biochemistry, JIPMER, Puducherry, India.
Department of Biochemistry, JIPMER, Puducherry, India.
Diabetes Metab Syndr. 2021 May-Jun;15(3):975-980. doi: 10.1016/j.dsx.2021.04.022. Epub 2021 Apr 27.
Comparison of the existence of metabolic syndrome, its components and their related biochemical complications between newly diagnosed and treated breast cancer patients.
Forty newly diagnosed untreated breast cancer patients and forty breast cancer patients who had received 7 cycles of neoadjuvant chemotherapy were recruited as group 1 and group 2 respectively. Height, weight, blood pressure, hormonal status, and tumor size were noted. The fasting blood glucose and lipid profile were estimated in AU 5811 Beckman coulter Clinical chemistry analyzer. Fasting insulin was estimated using Beckman Coulter access immunoassay system (UnicelDxI600). HbA1c assay was carried out in HPLC based ion exchange chromatography (Tosoh automated glycohemoglobin analyzer G8. Homeostasis Model Assessment 2-IR (HOMA 2-IR), HOMA-% B and HOMA-% S were calculated using an online calculator HOMA CALCULATOR [Oxford University]. Serum hsCRP and MDA were estimated by ELISA. FRAP assay was carried out manually to measure antioxidant status.
The existence of metabolic syndrome as well as type 2 diabetes was higher in the treated group when compared to the untreated patients. However, there were no significant differences in the indices of glucose homeostasis, low grade inflammation, oxidative stress and individual components of metabolic syndrome between the two groups. The triple negative patients were more prone to develop metabolic syndrome when compared to the triple positive patients.
Suitable therapeutic approaches may be planned out to address the metabolic syndrome and its related complications among breast cancer patients especially during the course of treatment.
比较新诊断和治疗的乳腺癌患者中代谢综合征的存在、其组成部分及其相关生化并发症。
招募 40 名新诊断未经治疗的乳腺癌患者和 40 名接受了 7 个周期新辅助化疗的乳腺癌患者分别作为第 1 组和第 2 组。记录身高、体重、血压、激素状态和肿瘤大小。使用 AU 5811 Beckman coulter 临床化学分析仪评估空腹血糖和血脂谱。使用 Beckman Coulter access immunoassay 系统（UnicelDxI600）估计空腹胰岛素。HbA1c 测定采用基于 HPLC 的离子交换色谱法（Tosoh 自动化糖化血红蛋白分析仪 G8）。使用在线计算器 HOMA CALCULATOR [Oxford University]计算稳态模型评估 2-IR（HOMA 2-IR）、HOMA-%B 和 HOMA-%S。通过 ELISA 估计血清 hsCRP 和 MDA。手动进行 FRAP 测定以测量抗氧化状态。
与未治疗患者相比，治疗组代谢综合征以及 2 型糖尿病的存在更高。然而，两组之间的葡萄糖稳态、低度炎症、氧化应激和代谢综合征的各个组成部分的指数没有显著差异。与三阳性患者相比，三阴性患者更容易发生代谢综合征。
可以制定适当的治疗方法来解决乳腺癌患者的代谢综合征及其相关并发症，尤其是在治疗过程中。
