University Hospital Würzburg, Department of Neurology, Josef-Schneider-Str. 11, 97080 Würzburg, Germany.
University Hospital Würzburg, Department of Neurology, Josef-Schneider-Str. 11, 97080 Würzburg, Germany.
J Neuroimmunol. 2021 Jul 15;356:577588. doi: 10.1016/j.jneuroim.2021.577588. Epub 2021 Apr 30.
Autoantibodies against agrin and cortactin have been described in patients with myasthenia gravis. To further validate and characterize these autoantibodies, sera and/or plasma exchange material of 135 patients with myasthenia gravis were screened for anti-agrin or anti-cortactin autoantibodies. Autoantibodies against cortactin were detected in three patients and two controls and could be confirmed by cell-based assays using cortactin-transfected human embryonic kidney cells in both controls and one patient, but were not detectable in follow-up sera of the three patients. We did not detect any autoantibodies against agrin. The clinical phenotype of anti-cortactin-positive patients varied, arguing against a relevant pathogenic role.
自身抗体对抗肌萎缩蛋白和桩蛋白已在重症肌无力患者中被描述。为了进一步验证和描述这些自身抗体，对 135 例重症肌无力患者的血清和/或血浆交换物进行了抗抗肌萎缩蛋白或抗桩蛋白自身抗体的筛选。在三名患者和两名对照者中检测到针对桩蛋白的自身抗体，并且可以通过使用转染有桩蛋白的人胚肾细胞的细胞基础测定在两名对照者和一名患者中得到证实，但在三名患者的随访血清中不可检测到。我们没有检测到任何针对抗肌萎缩蛋白的自身抗体。抗桩蛋白阳性患者的临床表型各不相同，这表明其没有相关的致病性作用。
