Narod S A
Department of Epidemiology and Community Medicine, University of Ottawa, Ontario.
Clin Invest Med. 1988 Apr;11(2):123-8.
Artificial insemination is currently offered in Ontario to couples when infertility arises from a male factor. The majority of practitioners are using fresh sperm, but because of the threat of transmitted infection, a change to the use of frozen semen, which can be screened concurrently, is anticipated. Screening can prevent the transmission of both genetic and infectious disease and the principles of a possible program are outlined below. Elements of screening include a genetic history, blood count, selected biochemical and serological assays, and a semen analysis and culture. Because of the high cost and the few cases of genetic disease that will be prevented, routine karyotyping is not recommended. It remains to be seen whether changing the donor pool from an unscreened group of medical personnel to a screened sperm bank derived from the general population will provide increased protection for the mother and child.
在安大略省，当不孕不育是由男性因素引起时，目前会为夫妇提供人工授精服务。大多数从业者使用的是新鲜精子，但由于存在传播感染的风险，预计会改用可同时进行筛查的冷冻精液。筛查可以预防遗传疾病和传染病的传播，下文概述了一个可能的筛查项目的原则。筛查内容包括遗传病史、血细胞计数、选定的生化和血清学检测，以及精液分析和培养。由于成本高昂且能预防的遗传疾病病例较少，不建议进行常规染色体核型分析。将供体库从未经筛查的医务人员群体改为从普通人群中筛选的精子库是否能为母婴提供更多保护，还有待观察。
