Institute of Biodiversity, Animal Health & Comparative Medicine, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, UK.
Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK.
Trends Parasitol. 2021 Sep;37(9):831-843. doi: 10.1016/j.pt.2021.04.007. Epub 2021 May 4.
Trypanocides are a key control component of African animal trypanosomiasis (AAT) in tsetse-infested areas of sub-Saharan Africa. While farmers are dependent upon trypanocides, recent research highlights their inappropriate and ineffective use, problems with drug quality, and treatment failure. There are currently gaps in knowledge and investment in inexpensive AAT diagnostics, understanding of drug resistance, and the effective use of trypanocides in the field. Without this important knowledge it is difficult to develop best practice and policy for existing drugs or to inform development and use of new drugs. There needs to be better understanding of the drivers and behavioural practices around trypanocide use so that they can be incorporated into sustainable solutions needed for the development of effective control of AAT.
杀锥虫剂是撒哈拉以南非洲采采蝇肆虐地区控制非洲动物锥虫病（AAT）的关键组成部分。尽管农民依赖杀锥虫剂，但最近的研究强调了其不适当和无效的使用、药物质量问题以及治疗失败。目前，在廉价 AAT 诊断、药物耐药性理解以及杀锥虫剂在现场的有效使用方面，知识和投资存在差距。如果没有这些重要的知识，就很难为现有药物制定最佳实践和政策，也无法为新药物的开发和使用提供信息。需要更好地了解杀锥虫剂使用的驱动因素和行为实践，以便将其纳入 AAT 有效控制所需的可持续解决方案中。
