一类新型抗寄生虫药物。
A new class of antiparasitic drugs.
机构信息
Department of Molecular and Cell Biology, Boston University Medical Campus, Boston, MA, USA.
出版信息
Science. 2023 Jun 30;380(6652):1320-1321. doi: 10.1126/science.adi5925. Epub 2023 Jun 29.
Abstract
Cyanotriazole compounds "poison" topoisomerase II of pathogenic trypanosomatids.
摘要
氰三唑类化合物“毒害”致病原生动物的拓扑异构酶 II。
相似文献
1
A new class of antiparasitic drugs.一类新型抗寄生虫药物。
Science. 2023 Jun 30;380(6652):1320-1321. doi: 10.1126/science.adi5925. Epub 2023 Jun 29.
2
The effect of topoisomerase II inhibitors on the kinetoplast ultrastructure.拓扑异构酶II抑制剂对动基体超微结构的影响。
Parasitol Res. 2004 Dec;94(6):439-48. doi: 10.1007/s00436-004-1223-4. Epub 2004 Oct 28.
3
DNA topoisomerases: a new twist for antiparasitic chemotherapy?DNA拓扑异构酶：抗寄生虫化疗的新契机？
Biochim Biophys Acta. 1998 Oct 1;1400(1-3):349-54. doi: 10.1016/s0167-4781(98)00146-8.
4
Novel findings on trypanosomatid chemotherapy using DNA topoisomerase inhibitors.使用DNA拓扑异构酶抑制剂治疗锥虫病的新发现。
Mini Rev Med Chem. 2009 Jun;9(6):674-86. doi: 10.2174/138955709788452775.
5
Design, synthesis, molecular docking and anti-proliferative evaluations of [1,2,4]triazolo[4,3-a]quinoxaline derivatives as DNA intercalators and Topoisomerase II inhibitors.设计、合成、分子对接及[1,2,4]三唑并[4,3-a]喹喔啉衍生物作为 DNA 嵌入剂和拓扑异构酶 II 抑制剂的抗增殖活性评价。
Bioorg Chem. 2020 Dec;105:104399. doi: 10.1016/j.bioorg.2020.104399. Epub 2020 Oct 21.
6
1,2-Naphthoquinone as a Poison of Human Type II Topoisomerases.1,2-萘醌类化合物作为人类Ⅱ型拓扑异构酶的毒物。
Chem Res Toxicol. 2021 Apr 19;34(4):1082-1090. doi: 10.1021/acs.chemrestox.0c00492. Epub 2021 Mar 24.
7
Synthesis, computational study and biological evaluation of 9-acridinyl and 1-coumarinyl-1,2,3-triazole-4-yl derivatives as topoisomerase II inhibitors.9-吖啶基和 1-香豆基-1,2,3-三唑-4-基衍生物的合成、计算研究及作为拓扑异构酶 II 抑制剂的生物评价。
J Enzyme Inhib Med Chem. 2022 Dec;37(1):502-513. doi: 10.1080/14756366.2021.2021898.
8
4β-amidotriazole linked podophyllotoxin congeners: DNA topoisomerase-IIα inhibition and potential anticancer agents for prostate cancer.4β-酰胺基三唑连接的鬼臼毒素类似物：DNA 拓扑异构酶-IIα 抑制和前列腺癌的潜在抗癌药物。
Eur J Med Chem. 2018 Jan 20;144:595-611. doi: 10.1016/j.ejmech.2017.12.050. Epub 2017 Dec 14.
9
Design and discovery of new 1,2,4-triazolo[4,3-c]quinazolines as potential DNA intercalators and topoisomerase II inhibitors.新型1,2,4-三唑并[4,3-c]喹唑啉类化合物作为潜在DNA嵌入剂和拓扑异构酶II抑制剂的设计与发现
Arch Pharm (Weinheim). 2021 Mar;354(3):e2000237. doi: 10.1002/ardp.202000237. Epub 2020 Nov 23.
10
Determination of the primary molecular target of 1,2,4-triazole-ciprofloxacin hybrids.1,2,4-三唑-环丙沙星杂合物主要分子靶点的测定
Molecules. 2015 Apr 9;20(4):6254-72. doi: 10.3390/molecules20046254.
本文引用的文献
1
Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections.氰基三唑类化合物是选择性拓扑异构酶 II 抑制剂，能迅速治愈锥虫感染。
Science. 2023 Jun 30;380(6652):1349-1356. doi: 10.1126/science.adh0614. Epub 2023 Jun 29.
2
Anti-trypanosomatid drug discovery: progress and challenges.抗利什曼原虫和锥虫药物研发：进展与挑战。
Nat Rev Microbiol. 2023 Jan;21(1):35-50. doi: 10.1038/s41579-022-00777-y. Epub 2022 Aug 22.
3
Oral fexinidazole for stage 1 or early stage 2 African Trypanosoma brucei gambiense trypanosomiasis: a prospective, multicentre, open-label, cohort study.口服非昔硝唑治疗 1 期或早期 2 期冈比亚布氏锥虫非洲锥虫病：一项前瞻性、多中心、开放性、队列研究。
Lancet Glob Health. 2021 Jul;9(7):e999-e1008. doi: 10.1016/S2214-109X(21)00208-4.
4
Topoisomerase II Poisons: Converting Essential Enzymes into Molecular Scissors.拓扑异构酶 II 抑制剂：将必需酶转化为分子剪刀。
Biochemistry. 2021 Jun 1;60(21):1630-1641. doi: 10.1021/acs.biochem.1c00240. Epub 2021 May 19.
5
Pharma to farmer: field challenges of optimizing trypanocide use in African animal trypanosomiasis.药企到农户：优化非洲动物锥虫病中杀锥虫剂使用的田间挑战。
Trends Parasitol. 2021 Sep;37(9):831-843. doi: 10.1016/j.pt.2021.04.007. Epub 2021 May 4.
6
Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice.布氏锥虫寄生虫占据小鼠脂肪组织并在功能上适应该组织。
Cell Host Microbe. 2016 Jun 8;19(6):837-48. doi: 10.1016/j.chom.2016.05.002. Epub 2016 May 26.
7
Gene expression in Kinetoplastids.动质体中的基因表达。
Curr Opin Microbiol. 2016 Aug;32:46-51. doi: 10.1016/j.mib.2016.04.018. Epub 2016 May 10.
8
Type IIA topoisomerase inhibition by a new class of antibacterial agents.新型抗菌药物对 IIA 拓扑异构酶的抑制作用。
Nature. 2010 Aug 19;466(7309):935-40. doi: 10.1038/nature09197. Epub 2010 Aug 4.
9
DNA topoisomerases and their poisoning by anticancer and antibacterial drugs.DNA拓扑异构酶及其被抗癌和抗菌药物抑制的情况。
Chem Biol. 2010 May 28;17(5):421-33. doi: 10.1016/j.chembiol.2010.04.012.
10
Distinct genes encode type II Topoisomerases for the nucleus and mitochondrion in the protozoan parasite Trypanosoma brucei.在原生动物寄生虫布氏锥虫中，细胞核和线粒体的II型拓扑异构酶由不同的基因编码。
J Biol Chem. 2006 Feb 10;281(6):3048-56. doi: 10.1074/jbc.M505977200. Epub 2005 Nov 28.
Zotero 插件