Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, SA 5000, Australia.
Centre for Cancer Biology, SA Pathology and the University of South Australia, Adelaide, SA 5000, Australia.
Trends Immunol. 2021 Jun;42(6):523-535. doi: 10.1016/j.it.2021.04.004. Epub 2021 May 4.
Mast cells (MC)s are evolutionarily conserved, tissue-resident immune cells with diverse roles in allergy, cancer, and protection from infection by helminths and microorganisms. The significant diversity in MC development and tissue-specific functional characteristics has recently begun to be understood. Exciting developments in single-cell-based RNA, protein, and chromatin profiling technologies offer new opportunities to characterize MC heterogeneity and to uncover novel MC functions and subtypes; these developments might lead to new and clinically effective therapies for certain pathologies. In this review, we provide an overview of the current understanding of MC development and heterogeneity and discuss new insights gained from single-cell-based studies that may lead to future research directions and therapeutic opportunities.
肥大细胞（MC）是进化上保守的组织驻留免疫细胞，在过敏、癌症以及对寄生虫和微生物感染的保护中具有多种作用。MC 发育和组织特异性功能特征的显著多样性最近才开始被理解。基于单细胞的 RNA、蛋白质和染色质分析技术的令人兴奋的发展为描述 MC 异质性和揭示新的 MC 功能和亚型提供了新的机会；这些发展可能为某些病理提供新的、有效的临床治疗方法。在这篇综述中，我们提供了对 MC 发育和异质性的当前理解的概述，并讨论了从单细胞研究中获得的新见解，这些见解可能为未来的研究方向和治疗机会提供指导。
