Schiavon R, Benavides S, Oropeza G, Garza-Flores J, Recio R, Díaz-Sanchez V, Pérez-Palacios G
Family Planning Service, General Hospital of Mexico, Mexico City.
Contraception. 1988 Jun;37(6):591-8. doi: 10.1016/0010-7824(88)90005-4.
To determine whether the long-term exposure to a monthly injectable contraceptive, containing dihydroxyprogesterone acetophenide 150 mg and estradiol enanthate 10 mg, induces significant changes on the serum estrogens profile and ovulation return in women, a study in chronic users was undertaken. Ovarian function was assessed for 3 months following a single injection of the contraceptive agent in a group of women (n = 7) who have been on this formulation for an average period of 6.7 years and in a non-user control group (n = 7). The serum concentrations of 17 beta-estradiol, estrone and progesterone were measured in samples drawn at regular intervals throughout the entire study. The endometrial bleeding pattern was recorded in all subjects. The results indicated that the post-injection serum estradiol maximum levels (exogenous peak) occurred significantly earlier (p less than 0.05) in chronic users as compared with the non-user control group. Baseline serum estrone concentrations were slightly higher in chronic users than those observed in the control group, while the values of serum 17 beta-estradiol did not exhibit significant differences among the two groups. Ovulation was documented within 60-90 days after injection in all subjects from both groups. A similar length of the first bleeding-free period was observed in all participants. The overall data provide evidence of a moderate increase of estrone, one of the still active metabolic conversion products of 17 beta-estradiol, in the sera of chronic users of this combined contraceptive without affecting its pharmacodynamics.
为了确定长期使用一种每月注射一次的避孕药（含150毫克醋炔诺醇二羟孕酮和10毫克庚酸雌二醇）是否会引起女性血清雌激素水平和排卵恢复的显著变化，对长期使用者进行了一项研究。在一组平均使用该制剂6.7年的女性（n = 7）和一个非使用者对照组（n = 7）中，在单次注射避孕药后评估3个月的卵巢功能。在整个研究过程中定期采集样本，测量血清中17β-雌二醇、雌酮和孕酮的浓度。记录所有受试者的子宫内膜出血模式。结果表明，与非使用者对照组相比，长期使用者注射后血清雌二醇的最高水平（外源性峰值）出现得明显更早（p < 0.05）。长期使用者的基线血清雌酮浓度略高于对照组，而两组血清17β-雌二醇的值没有显著差异。两组所有受试者在注射后60 - 90天内均记录到排卵。所有参与者的首个无出血期长度相似。总体数据表明，在这种复方避孕药的长期使用者血清中，作为17β-雌二醇仍具有活性的代谢转化产物之一的雌酮适度增加，且不影响其药效学。
