Bassol S, Hernandez C, Nava M P, Trujillo A M, Luz de la Cruz D
Department of Reproductive Biology, Medicine School of Torreon, University of Coahuila, Mexico.
Contraception. 1995 May;51(5):307-11. doi: 10.1016/0010-7824(95)00080-t.
A comparative study was undertaken involving 21 Mexican women who discontinued the use of medroxyprogesterone acetate 25 mg plus oestradiol cypionate 5 mg (Cyclofem) and norethisterone enanthate 50 mg plus oestradiol valerate 5 mg (Mesigyna) to assess the time required for the return to menses and ovulation. All subjects were exposed to once-a-month injectable contraceptives for two years and were followed for 120 days after the last injection. The urinary concentration of oestrone glucuronide and pregnanediol glucuronide was determined daily in all subjects beginning one month after the last injection. The results disclosed that ovulatory cycles were documented after 120 days of the last injection in six women of each studied group. Similar endometrial bleeding patterns were observed in both groups, indicating that the two drugs have alike pharmacokinetic and pharmacodynamic effects.
开展了一项对比研究，涉及21名墨西哥女性，她们停用了醋酸甲羟孕酮25毫克加环戊丙酸雌二醇5毫克（Cyclofem）以及庚酸炔诺酮50毫克加戊酸雌二醇5毫克（Mesigyna），以评估恢复月经和排卵所需的时间。所有受试者接受每月一次的注射用避孕药两年，并在最后一次注射后随访120天。从最后一次注射后一个月开始，每天测定所有受试者尿液中雌酮葡萄糖醛酸苷和孕二醇葡萄糖醛酸苷的浓度。结果显示，在每个研究组的6名女性中，最后一次注射120天后记录到了排卵周期。两组观察到相似的子宫内膜出血模式，表明这两种药物具有相似的药代动力学和药效学作用。
