Bassol S, Garza-Flores J
Department of Reproductive Biology, School of Medicine, University of Coahuila, Torreon, Mexico.
Contraception. 1994 May;49(5):441-53. doi: 10.1016/0010-7824(94)90003-5.
Once-a-month combined injectable preparations draw their contraceptive efficacy from continuous ovulation suppression. When their use is discontinued, ovulation resumes within a few weeks or a few months, depending on the formulation. After use of the dihydroxyprogesterone acetophenide 150 mg/estradiol enanthate 5 mg combination for one to two years, ovulation returns in most subjects 3-4 months after discontinuation of treatment. Similarly, recent data show that after 2-year use of the depot-medroxyprogesterone acetate 25 mg/estradiol cypionate 5 mg or the norethisterone enanthate 50 mg/estradiol valerate 5 mg combination, approximately 70% women have resumed ovulation by the third month post-treatment. This is shorter than the time for return of ovulation experienced by ex-users of progestogen-only injectable contraceptives.
每月一次的复方注射制剂通过持续抑制排卵发挥避孕作用。停药后，排卵会在几周或几个月内恢复，具体时间取决于制剂类型。使用150毫克醋炔羟孕酮/5毫克戊酸雌二醇组合制剂一至两年后，大多数使用者在停药后3至4个月恢复排卵。同样，近期数据表明，使用25毫克醋酸甲羟孕酮/5毫克环丙孕酮酯或50毫克庚酸炔诺酮/5毫克戊酸雌二醇组合制剂两年后，约70%的女性在治疗后第三个月恢复排卵。这比仅使用孕激素的注射用避孕药使用者恢复排卵的时间要短。
