Talia Karen L, Parra-Herran Carlos, McCluggage W Glenn
Department of Pathology, Royal Women's Hospital and VCS Foundation, Melbourne, Australia.
Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.
Histopathology. 2022 Jan;80(2):255-278. doi: 10.1111/his.14399. Epub 2021 Oct 20.
The morphological spectrum of primary ovarian mucinous and seromucinous tumours is broad, and presents an array of diagnostic challenges, many unique to these tumour types. This reflects the heterogeneous nature of these lesions, their varied histogenesis and evolving classification systems over recent decades, with further modification to the seromucinous category incorporated in the recently published 5th edition of the World Health Organisation (WHO) Classification of female genital tumours. In this review we provide an update on the classification of these neoplasms and discuss their histogenesis and diverse morphology, focusing on areas which are diagnostically problematic. We also cover tumour grading, differential diagnosis, immunohistochemistry, the recent elucidation of the molecular underpinnings of ovarian mucinous neoplasia and discuss the gross and intra-operative handling of these tumours. A number of diagnostic issues remain unresolved, highlighting the importance of further research on this front, as well as a multidisciplinary approach in the care of patients with ovarian mucinous and seromucinous neoplasia.
原发性卵巢黏液性和浆液黏液性肿瘤的形态学谱广泛，带来了一系列诊断挑战，其中许多挑战是这些肿瘤类型所特有的。这反映了这些病变的异质性、它们多样的组织发生以及近几十年来不断演变的分类系统，最近出版的第5版世界卫生组织（WHO）女性生殖器官肿瘤分类中对浆液黏液性类别进行了进一步修订。在本综述中，我们提供了这些肿瘤分类的最新情况，并讨论它们的组织发生和多样的形态学，重点关注诊断有问题的领域。我们还涵盖肿瘤分级、鉴别诊断、免疫组织化学、卵巢黏液性肿瘤形成的分子基础的最新阐明，并讨论这些肿瘤的大体和术中处理。一些诊断问题仍未解决，突出了在这方面进一步研究的重要性，以及对卵巢黏液性和浆液黏液性肿瘤患者进行多学科护理的重要性。
