Tecnológico de Monterrey, Escuela de Ingeniería y Ciencias, Centro de Biotecnología FEMSA, Eugenio Garza Sada 2501 Sur, C.P., 64849, Monterrey, N.L., Mexico.
Tecnológico de Monterrey, Escuela de Ingeniería y Ciencias, Centro de Biotecnología FEMSA, Eugenio Garza Sada 2501 Sur, C.P., 64849, Monterrey, N.L., Mexico.
J Biotechnol. 2021 Jun 10;333:77-85. doi: 10.1016/j.jbiotec.2021.04.009. Epub 2021 May 5.
Capsaicinoids confer the pungency in chili peppers and are proven to contain many beneficial traits, among them analgesic and anti-inflammatory properties. Capsaicinoids produce a burning sensation when administered and have other secondary effects given their pungency. This is why many drug delivery vehicles have been tested to prove their efficacy in reducing the secondary effects of these compounds while still having its primary beneficial effects. There are many articles that talk about the formulation of drug delivery systems and their properties yet there is little information on the therapeutic effects of applying these drug delivery systems. This review is focused on studies' results that prove efficacy of capsaicinoids specially in those that use them in nano-sized drug delivery systems. Nano-sized carriers have been proven to reduce the secondary effects of capsaicinoids while improving the bioavailability, absorption, anti-inflammatory and analgesic properties of these compounds.
辣椒素使辣椒具有辛辣味，并已被证明具有许多有益特性，包括镇痛和抗炎特性。辣椒素在给药时会产生烧灼感，并因其辛辣味而产生其他次要作用。这就是为什么已经测试了许多药物输送载体来证明它们在减少这些化合物的次要作用的同时仍具有主要有益作用的原因。有许多文章讨论了药物输送系统的配方及其特性，但关于应用这些药物输送系统的治疗效果的信息却很少。这篇综述重点介绍了证明辣椒素特别是在使用纳米级药物输送系统的研究结果的有效性。已经证明，纳米载体可以减少辣椒素的次要作用，同时提高这些化合物的生物利用度、吸收、抗炎和镇痛特性。
