Academic Unit of Neurology, Trinity College Dublin, the University of Dublin, Dublin 2, Ireland.
Academic Unit of Neurology, Trinity College Dublin, the University of Dublin, Dublin 2, Ireland; Department of Neurology, University Medical Centre Utrecht Brain Centre, Utrecht University, Utrecht, The Netherlands.
Neurobiol Aging. 2021 Aug;104:57-70. doi: 10.1016/j.neurobiolaging.2021.03.002. Epub 2021 Mar 10.
We aimed to quantitatively characterize progressive brain network disruption in Amyotrophic Lateral Sclerosis (ALS) during cognition using the mismatch negativity (MMN), an electrophysiological index of attention switching. We measured the MMN using 128-channel EEG longitudinally (2-5 timepoints) in 60 ALS patients and cross-sectionally in 62 healthy controls. Using dipole fitting and linearly constrained minimum variance beamforming we investigated cortical source activity changes over time. In ALS, the inferior frontal gyri (IFG) show significantly lower baseline activity compared to controls. The right IFG and both superior temporal gyri (STG) become progressively hyperactive longitudinally. By contrast, the left motor and dorsolateral prefrontal cortices are initially hyperactive, declining progressively. Baseline motor hyperactivity correlates with cognitive disinhibition, and lower baseline IFG activities correlate with motor decline rate, while left dorsolateral prefrontal activity predicted cognitive and behavioural impairment. Shorter survival correlates with reduced baseline IFG and STG activity and later STG hyperactivation. Source-resolved EEG facilitates quantitative characterization of symptom-associated and symptom-preceding motor and cognitive-behavioral cortical network decline in ALS.
我们旨在使用错误相关负波（MMN），一种注意力转换的电生理指标，定量描述肌萎缩侧索硬化症（ALS）患者认知过程中大脑网络的渐进性破坏。我们使用 128 通道 EEG 对 60 名 ALS 患者进行了纵向（2-5 个时间点）测量，并对 62 名健康对照者进行了横向测量。我们通过偶极子拟合和线性约束最小方差波束形成来研究皮质源活动随时间的变化。在 ALS 患者中，下额前回（IFG）的基线活动明显低于对照组。右侧 IFG 和双侧颞上回（STG）的活动随时间逐渐增加。相比之下，左侧运动前区和背外侧前额叶皮层最初是活跃的，然后逐渐下降。基线运动活动与认知抑制有关，而较低的 IFG 活动与运动下降率有关，而左侧背外侧前额叶活动则预测认知和行为障碍。较短的生存期与 IFG 和 STG 基线活动的降低以及 STG 后期的过度活跃有关。基于源的 EEG 有助于定量描述 ALS 患者与症状相关和症状前的运动及认知行为皮质网络的下降。
