基于体表面积的ω-3 脂肪酸补充与儿童血液浓度密切相关。

Body surface area-based omega-3 fatty acids supplementation strongly correlates to blood concentrations in children.

机构信息

Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.

出版信息

Prostaglandins Leukot Essent Fatty Acids. 2021 Jun;169:102285. doi: 10.1016/j.plefa.2021.102285. Epub 2021 Apr 24.

DOI:10.1016/j.plefa.2021.102285

Abstract

Omega-3 fatty acids have been suggested as a complement in cancer treatment, but doses are not established. We performed a dose-finding study in 33 children in remission from cancer. Participants were allocated to a body surface area (BSA) adjusted dose (mg/m) of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) (40:60), ranging 233-3448 mg/m daily for 90 days. Fatty acid concentration in plasma phospholipids and red blood cells were determined by GC. Supplementation was well tolerated and correlated strongly with blood ω3-fatty acid concentrations and EPA showed the highest increase. Using the ω3-index disregards docosapentaenoic acid (DPA), which increased 30-43% in our study motivating an EDD-index (∑EPA,DPA,DHA). The ratio between arachidonic acid and EPA or DHA showed negative exponential trends. Dose per BSA enabled an individualized omega-3 supplementation decreasing the variation referred to interindividual differences. Based on our results, we suggest a dose of 1500 mg/m BSA for further studies.

摘要

ω-3 脂肪酸已被提议作为癌症治疗的辅助手段，但剂量尚未确定。我们在 33 名癌症缓解期的儿童中进行了一项剂量探索研究。参与者按照体表面积（BSA）调整的二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）（40:60）剂量（mg/m）进行分配，每天接受 233-3448mg/m 的剂量，持续 90 天。通过 GC 测定血浆磷脂和红细胞中的脂肪酸浓度。补充剂耐受性良好，与血液 ω3 脂肪酸浓度密切相关，EPA 增加最多。使用 ω3 指数忽略了二十二碳五烯酸（DPA），在我们的研究中，DPA 增加了 30-43%，这促使我们提出 EDD 指数（∑EPA、DPA、DHA）。花生四烯酸与 EPA 或 DHA 的比值呈负指数趋势。BSA 剂量可实现个体化的 ω-3 补充，减少了个体间差异的差异。基于我们的结果，我们建议进一步研究的 BSA 剂量为 1500mg/m。