Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No.119, South 4th Ring West Road, Fengtai District, Beijing, 100070, China.
China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
BMC Neurol. 2021 May 8;21(1):186. doi: 10.1186/s12883-021-02188-7.
When dizziness/vertigo patients presented with balance disorder, it will bring severe morbidity. There is currently lack of research to explore risk factor related balance disorder in dizziness patients, especially in those who walk independently.
To investigate risk factors related balance disorder in dizziness/vertigo patients who walk independently.
Medical data of 1002 dizziness/vertigo patients registered in vertigo/balance disorder registration database were reviewed. The demographic data, medical history, and risk factors for atherosclerosis (AS) were collected. Enrolled dizziness/vertigo patients could walk independently, completed Romberg test, videonystagmography (VNG), and limits of stability (LOS). The subjective imbalance was patient complained of postural symptom when performing Romberg test. Multivariable logistic regression analyzed risk factors related balance disorder. The receiver operating characteristic (ROC) curve evaluated the utility of regression model.
Five hundred fifty-three dizziness/vertigo patients who walk independently were included in the final analysis. According to LOS, patients were divided into 334 (60%) normal balance and 219 (40%) balance disorder. Compared with normal balance, patients with balance disorder were older (P = 0.045) and had more risk factors for AS (P<0.0001). The regression showed that risk factors for AS (OR 1.494, 95% CI 1.198-1.863), subjective imbalance (OR 4.835, 95% CI 3.047-7.673), and abnormality of optokinetic nystagmus (OR 8.308, 95% CI 1.576-43.789) were related to balance disorder. The sensitivity and specificity of model were 71 and 63% (P<0.0001). The area under the curve (AUC) was 0.721.
Risk factors for AS, subjective imbalance, and abnormality of optokinetic nystagmus were predictors for balance disorder in patients with dizziness/vertigo who walk independently.
当头晕/眩晕患者出现平衡障碍时，会带来严重的发病率。目前缺乏研究来探索头晕患者平衡障碍的相关危险因素，特别是那些能够独立行走的患者。
探讨能够独立行走的头晕/眩晕患者平衡障碍的相关危险因素。
回顾性分析眩晕/平衡障碍登记数据库中登记的 1002 例头晕/眩晕患者的医疗数据。收集患者的人口统计学数据、病史和动脉粥样硬化（AS）危险因素。纳入的头晕/眩晕患者能够独立行走，完成 Romberg 试验、视频眼震图（VNG）和稳定性极限（LOS）检查。主观失衡是指患者在进行 Romberg 试验时主诉姿势症状。多变量逻辑回归分析平衡障碍的相关危险因素。受试者工作特征（ROC）曲线评估回归模型的效用。
最终纳入 553 例能够独立行走的头晕/眩晕患者进行分析。根据 LOS，患者分为 334 例（60%）平衡正常和 219 例（40%）平衡障碍。与平衡正常组相比，平衡障碍组患者年龄更大（P=0.045），且具有更多的 AS 危险因素（P<0.0001）。回归分析显示，AS 危险因素（OR 1.494，95%CI 1.198-1.863）、主观失衡（OR 4.835，95%CI 3.047-7.673）和视动性眼震异常（OR 8.308，95%CI 1.576-43.789）与平衡障碍相关。模型的灵敏度和特异度分别为 71%和 63%（P<0.0001）。曲线下面积（AUC）为 0.721。
AS 危险因素、主观失衡和视动性眼震异常是能够独立行走的头晕/眩晕患者平衡障碍的预测因素。
