Laboratorio de Investigación en Tuberculosis Bovina, Departamento de Microbiología e Inmunología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Mexico city, Mexico.
Departamento de Patología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Mexico city, Mexico.
BMC Vet Res. 2021 May 8;17(1):187. doi: 10.1186/s12917-021-02893-y.
Bovine tuberculosis is a chronic inflammatory disease that causes granuloma formation mainly in retropharyngeal, tracheobronchial, mediastinal lymph nodes and lungs of bovines. The presence of these lesions in other tissues such as the eyeball is very rare and difficult to diagnose. This study describes macroscopic and microscopic pathological findings in a calf with ocular and meningeal tuberculosis.
March 2019, an eight-month-old Holstein Friesian calf was identified in a dairy farm located in central Mexico with a clinical cough, anorexia, incoordination, corneal opacity and vision loss. At necropsy, pneumonia, lymphadenitis, meningitis, and granulomatous iridocyclitis were observed. The histopathological examination revealed granulomatous lesions in lung tissue, lymph nodes, meninges and eyes with the presence of acid-fast bacilli associated with Mycobacterium spp.
To the best of our knowledge, this is the first report that describes macroscopic and microscopic pathological findings of ocular tuberculosis in cattle. This report highlights the importance of considering bovine tuberculosis in the differential diagnosis of corneal opacity and loss of vision in cattle.
牛结核病是一种慢性炎症性疾病，主要导致牛的咽后、气管支气管、纵隔淋巴结和肺部形成肉芽肿。这些病变出现在眼球等其他组织中非常罕见，也很难诊断。本研究描述了一例具有眼和脑膜结核的小牛的大体和显微镜病理发现。
2019 年 3 月，在墨西哥中部的一个奶牛场发现一头 8 个月大的荷斯坦弗里生小牛，表现出临床咳嗽、食欲不振、共济失调、角膜混浊和视力丧失。剖检时，观察到肺炎、淋巴结炎、脑膜炎和肉芽肿性虹膜睫状体炎。组织病理学检查显示肺部组织、淋巴结、脑膜和眼睛中存在肉芽肿性病变，存在与分枝杆菌属相关的抗酸杆菌。
据我们所知，这是首次描述牛眼结核病的大体和显微镜病理发现。本报告强调了在牛角膜混浊和视力丧失的鉴别诊断中考虑牛结核病的重要性。
