Williams C M, Lines C M, McKay E C
Department of Biochemistry, University of Surrey, Guildford, UK.
Eur J Clin Nutr. 1988 Apr;42(4):321-8.
Measurements of weighted dietary intakes and plasma determinations of albumin, iron, zinc, ascorbic acid and TIBC were carried out on twenty female multiple sclerosis patients in a long-stay hospital for disabled people. The group included ten patients with a recent history of pressure sores, closely matched with ten patients without pressure sores. Mean daily intake of carbohydrate was found to be higher in the non-pressure sore group whilst intake of zinc was lower in this group. Intakes of all other nutrients were comparable between the two groups. For both groups, intakes of energy, folate, vitamin D, iron and zinc were less than recommended values. Mean plasma levels of albumin and iron were towards the lower limit of the normal range, whilst that for zinc was considerably less than the normal range. Plasma TIBC was slightly above the normal range. Levels of plasma iron and zinc were significantly lower in the pressure sore group. The data indicate that severely disabled hospitalized patients with multiple sclerosis may be at risk of poor nutritional status. The results suggest that in the presence of pressure sores, there are increased requirements for specific nutrients, notably zinc and iron. Consideration is given to the possible value of supplementation of these individuals.
对一家残疾人长期住院医院的20名女性多发性硬化症患者进行了膳食摄入量加权测量以及血浆白蛋白、铁、锌、抗坏血酸和总铁结合力（TIBC）的测定。该组包括10名近期有压疮病史的患者，与10名无压疮患者进行了密切匹配。发现非压疮组的碳水化合物平均每日摄入量较高，而该组的锌摄入量较低。两组之间所有其他营养素的摄入量相当。对于两组患者，能量、叶酸、维生素D、铁和锌的摄入量均低于推荐值。血浆白蛋白和铁的平均水平接近正常范围下限，而锌的水平则远低于正常范围。血浆TIBC略高于正常范围。压疮组的血浆铁和锌水平显著较低。数据表明，重度残疾的住院多发性硬化症患者可能存在营养状况不佳的风险。结果表明，在有压疮的情况下，对特定营养素，尤其是锌和铁的需求增加。考虑了对这些个体进行补充的可能价值。
