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良性食管疾病行结肠代食管术后的营养状况

Nutritional state after colon interposition for benign oesophageal disease.

作者信息

Harju E, Isolauri J

机构信息

Department of Clinical Sciences, University of Tampere, Finland.

出版信息

Eur J Clin Nutr. 1988 Apr;42(4):351-7.

PMID:3396526
Abstract

The nutritional state of 32 patients after (mean 66 months) colon interposition due to benign oesophageal disease was examined. Forty-four per cent of the patients had depleted iron stores (low serum ferritin concentration). Serum iron and blood haemoglobin concentrations were lower (P less than 0.001) in those with low than in those with normal serum ferritin concentration (115 +/- 12 g/l and 15 +/- 5 mumol/l vs 135 +/- 12 g/l and 23 +/- 9 mumol/l). Most very low blood haemoglobin concentrations (less than 110 g/l) were found in patients with depleted iron stores. Eighteen patients had serum albumin concentrations slightly below (35-39 g/l) the normal range, and two other patients had values less than 35 g/l. The patients had less dietary iron (13 +/- 6 mg/d) than age- and sex-matched controls (19 +/- 7 mg/d), but the intake of patients with depleted iron stores (12 +/- 5 mg/d) was similar to that of patients with normal iron stores (14 +/- 6 mg/d). Symptoms and/or the replacement of colon graft anti- or isoperistaltically did not have any significant association with the nutritional status, only slightly reduced blood haemoglobin and serum albumin concentration were found among the symptomatic patients and the patients with an antiperistaltic graft. Iron therapy and protein supplements, eg, from milk, egg, soy and meat, are recommended as the dietary treatment. To improve the nutritional status a short intra-abdominal colon graft loop anastomosed to the proximal stomach instead of long loop with an antral anastomosis of the present patients is suggested.

摘要

对32例因良性食管疾病行结肠间置术(平均66个月后)患者的营养状况进行了检查。44%的患者铁储备耗竭(血清铁蛋白浓度低)。血清铁蛋白浓度低的患者血清铁和血红蛋白浓度较低(P<0.001)(分别为115±12g/L和15±5μmol/L,而血清铁蛋白浓度正常者为135±12g/L和23±9μmol/L)。血红蛋白浓度极低(<110g/L)的情况多见于铁储备耗竭的患者。18例患者血清白蛋白浓度略低于正常范围(35 - 39g/L),另外2例患者的值低于35g/L。患者饮食中铁摄入量(13±6mg/d)低于年龄和性别匹配的对照组(19±7mg/d),但铁储备耗竭患者(12±5mg/d)的摄入量与铁储备正常患者(14±6mg/d)相似。症状和/或结肠移植物抗蠕动或顺蠕动替代与营养状况无显著关联,仅在有症状的患者和抗蠕动移植物患者中发现血红蛋白和血清白蛋白浓度略有降低。建议采用铁剂治疗和蛋白质补充剂,如来自牛奶、鸡蛋、大豆和肉类的补充剂作为饮食治疗。为改善营养状况,建议对本研究患者采用近端胃吻合的短腹腔内结肠移植物袢,而非目前的远端吻合长袢。

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