选择性 G 蛋白偶联受体定位和转运的机制。
Mechanisms of selective G protein-coupled receptor localization and trafficking.
机构信息
Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI, USA.
Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI, USA.
出版信息
Curr Opin Cell Biol. 2021 Aug;71:158-165. doi: 10.1016/j.ceb.2021.03.002. Epub 2021 May 7.
Abstract
The trafficking of G protein-coupled receptors (GPCRs) to different membrane compartments has recently emerged as being a critical determinant of the signaling profiles of activation. GPCRs, which share many structural and functional similarities, also share many mechanisms that traffic them between compartments. This sharing raises the question of how the trafficking of individual GPCRs is selectively regulated. Here, we will discuss recent studies addressing the mechanisms that contribute to selectivity in endocytic and biosynthetic trafficking of GPCRs.
摘要
G 蛋白偶联受体（GPCRs）向不同膜区室的转运最近已成为激活信号谱的关键决定因素。GPCR 具有许多结构和功能上的相似性，也具有许多将它们在区室之间运输的机制。这种共享提出了一个问题，即如何选择性地调节个别 GPCR 的运输。在这里，我们将讨论最近的研究，这些研究探讨了有助于 GPCR 内吞和生物合成运输中选择性的机制。
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