神经元 G 蛋白偶联受体的基于位置的信号输出的多样性和特异性。
Diversity and specificity in location-based signaling outputs of neuronal GPCRs.
机构信息
Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: https://twitter.com/ityadi_.
Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
出版信息
Curr Opin Neurobiol. 2022 Oct;76:102601. doi: 10.1016/j.conb.2022.102601. Epub 2022 Jul 4.
Abstract
The common mechanisms by which members of the G protein-coupled receptor (GPCR) family respond to neurotransmitters in the brain have been well studied. However, it is becoming increasingly clear that GPCRs show great diversity in their intracellular location, interacting partners and effectors, and signaling consequences. Here we will discuss recent studies on the diversity of location, effectors, and signaling of GPCRs, and how these could interact to generate specific spatiotemporal patterns of GPCR signaling in cells.
摘要
G 蛋白偶联受体（GPCR）家族成员在大脑中对神经递质产生反应的常见机制已经得到了很好的研究。然而，越来越明显的是，GPCR 在其细胞内位置、相互作用伙伴和效应器以及信号转导后果方面表现出很大的多样性。在这里，我们将讨论最近关于 GPCR 位置、效应器和信号转导多样性的研究，以及这些如何相互作用以在细胞中产生特定的 GPCR 信号时空模式。
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