Górski J, Nowacka M, Namiot Z, Puch U
Department of Physiology, Medical School, Białystok, Poland.
Eur J Appl Physiol Occup Physiol. 1988;57(5):554-7. doi: 10.1007/BF00418461.
This study examined the effect of prolonged exercise on the level of triglycerides (TG) in rat liver. The rats were divided into groups: 1-control, 2-treated with nicotinic acid, 3-fed with glucose during exercise, 4-fasted, 5-adrenalectomized, 6-adrenalectomized and fed with oil. In the control group, there was gradual accumulation of TG in the liver and their level was doubled at exhaustion as compared to the resting value. Nicotinic acid lowered the resting level of TG and prevented their accumulation during exercise. Administration of glucose during exercise partially prevented the increase in TG level in the liver. In rats fasted for 24 h before exercise, the net increase in liver TG level during exercise was similar to that in the controls. Adrenalectomy, like nicotinic acid, lowered TG level at rest and prevented its increase during exercise. Feeding the adrenalectomized rats with oil elevated the plasma free fatty acid level but did not result in accumulation of TG in the liver, either at rest or during exercise. It is concluded that prolonged exercise results in accumulation of TG in the liver and that the process depends on the supply of free fatty acids and glucose and requires the presence of glucocorticoids.
本研究检测了长时间运动对大鼠肝脏甘油三酯（TG）水平的影响。将大鼠分为以下几组：1-对照组，2-用烟酸处理组，3-运动期间喂食葡萄糖组，4-禁食组，5-肾上腺切除组，6-肾上腺切除并喂食油组。在对照组中，肝脏中TG逐渐积累，与静息值相比，运动至疲劳时其水平翻倍。烟酸降低了TG的静息水平，并防止其在运动期间积累。运动期间给予葡萄糖可部分阻止肝脏中TG水平的升高。在运动前禁食24小时的大鼠中，运动期间肝脏TG水平的净增加与对照组相似。肾上腺切除与烟酸一样，降低了静息时的TG水平，并防止其在运动期间升高。给肾上腺切除的大鼠喂食油可提高血浆游离脂肪酸水平，但在静息或运动时均未导致肝脏中TG的积累。研究得出结论，长时间运动导致肝脏中TG积累，该过程取决于游离脂肪酸和葡萄糖的供应，并且需要糖皮质激素的存在。
