Oscai L B, Caruso R A, Wergeles A C
J Appl Physiol Respir Environ Exerc Physiol. 1982 Apr;52(4):1059-63. doi: 10.1152/jappl.1982.52.4.1059.
A strenuous program of treadmill running increased endogenous lipoprotein lipase (LPL) activity 2.7-fold in the soleus and 2.8-fold in fast-red fibers of the quadriceps. Under these conditions, intracellular triacylglycerols (TG) decreased 25% in the soleus and 44% in fast-red muscle fibers. Free fatty acids (FFA) increased 2.1-fold (soleus) and 2.7-fold (fast-red). In the heart, a 2-h bout of swimming in untrained rats increased intracellular LPL activity 64% measured 24 h after work. The magnitude of the increase in endogenous LPL activity in heart was dependent on the intensity of the exercise. With elevated levels of intracellular LPL activity in the myocardium, TG was reduced 49% and FFA increased 3.4-fold. These results provide evidence that exercise may result in an increased capacity to hydrolyze intramuscular TG. Further, they suggest that LPL may be the enzyme responsible for intracellular TG hydrolysis in heart and skeletal muscle.
高强度的跑步机跑步计划使比目鱼肌内源性脂蛋白脂肪酶（LPL）活性提高了2.7倍，股四头肌快红肌纤维中的该酶活性提高了2.8倍。在这些条件下，比目鱼肌内的细胞内甘油三酯（TG）减少了25%，快红肌纤维中的细胞内甘油三酯减少了44%。游离脂肪酸（FFA）增加了2.1倍（比目鱼肌）和2.7倍（快红肌）。在心脏中，未训练的大鼠进行2小时的游泳运动后，在运动后24小时测量发现细胞内LPL活性增加了64%。心脏中内源性LPL活性增加的幅度取决于运动强度。随着心肌细胞内LPL活性水平的升高，TG减少了49%，FFA增加了3.4倍。这些结果证明运动可能会导致肌肉内TG水解能力的提高。此外，它们表明LPL可能是负责心脏和骨骼肌细胞内TG水解的酶。
