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动机性访谈治疗大麻使用障碍:系统评价和荟萃分析。

Motivational Interviewing for Cannabis Use Disorders: A Systematic Review and Meta-Analysis.

机构信息

Faculty of Medicine, University of Barcelona, Barcelona, Spain.

Grup Recerca Addiccions Clínic (GRAC-GRE), Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Hospital Clínic Barcelona, Barcelona, Spain.

出版信息

Eur Addict Res. 2021;27(6):413-427. doi: 10.1159/000515667. Epub 2021 May 7.

Abstract

BACKGROUND

Cannabis is one of the most used drugs worldwide. There is no gold standard treatment for cannabis use disorder (CUD). Motivational interviewing (MI) has shown efficacy in some substance use disorders. Therefore, a systematic review was conducted to assess the effectiveness of MI in CUD.

METHODS

Randomized controlled trials or open-label studies published until September 2019 from 3 different databases (Pubmed, Scopus, and PsycINFO) were included, following the PRISMA guidelines and a predetermined set of criteria for article selection. Meta-analyses were conducted. The end point was determined as month 3, and 4 outcomes were analysed (abstinence rates, reduction in frequency of use, reduction in quantity of use, and reduction in cannabis use disorder symptoms) in 2 populations (adolescents and adults).

RESULTS

Forty studies were identified, of which 24 were performed in adults and 16 in adolescents. MI showed efficacy in achieving abstinence in both adults (odds ratio [OR] = 3.84, 95% confidence interval [CI] 2.40-6.16, p < 0.0001) and adolescents (OR = 2.02, 95% CI 1.42-2.89, p < 0.0001). MI showed efficacy in reducing frequency and quantity of use in adults but not in adolescents. Those adults who were in the MI group consumed less joints per day than those in the control group (mean difference = -0.69 joints per day, 95% CI -0.84 to -0.53, p < 0.001), and they consumed on less days per month (mean difference = -3.9 days per month, 95% CI -7.47 to -0.34, p = 0.0317) than those in the control group.

CONCLUSIONS

MI is an effective intervention to reduce cannabis use and achieve abstinence, especially among adults and patients with no prior history of psychotic disorder. Further investigation is needed to assess the effect on CUD symptoms. MI should be included in guidelines for treating cannabis use disorder as one of the essential psychological interventions.

摘要

背景

大麻是全球使用最广泛的毒品之一。目前尚无治疗大麻使用障碍(CUD)的金标准疗法。动机访谈(MI)已被证明对某些物质使用障碍有效。因此,进行了系统评价以评估 MI 在 CUD 中的疗效。

方法

纳入了截至 2019 年 9 月在 3 个不同数据库(Pubmed、Scopus 和 PsycINFO)上发表的随机对照试验或开放标签研究,遵循 PRISMA 指南和一套预定的文章选择标准。进行了荟萃分析。终点定为第 3 个月,分析了 2 个人群(青少年和成年人)的 4 个结局(戒断率、使用频率降低、使用量减少和大麻使用障碍症状减少)。

结果

共确定了 40 项研究,其中 24 项在成年人中进行,16 项在青少年中进行。MI 在实现成人(比值比[OR] = 3.84,95%置信区间[CI] 2.40-6.16,p < 0.0001)和青少年(OR = 2.02,95% CI 1.42-2.89,p < 0.0001)的戒断方面均有效。MI 在减少成年人的使用频率和使用量方面有效,但在青少年中无效。与对照组相比,接受 MI 治疗的成年人每天吸烟的数量减少(平均差异=-0.69 支,95% CI -0.84 至-0.53,p < 0.001),且每月吸烟天数减少(平均差异=-3.9 天,95% CI -7.47 至-0.34,p = 0.0317)。

结论

MI 是一种有效减少大麻使用并实现戒断的干预措施,尤其适用于成年人和无精神病病史的患者。需要进一步研究以评估对 CUD 症状的影响。MI 应作为治疗大麻使用障碍的基本心理干预措施之一纳入指南。

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