Division of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Curr Opin Endocrinol Diabetes Obes. 2021 Aug 1;28(4):348-353. doi: 10.1097/MED.0000000000000639.
This review briefly summarizes the growing body of literature addressing the skeletal consequences of sleep and circadian disruption.
The most recent data in the field suggest that the diurnal variation in bone turnover markers are because of endogenous circadian rhythmicity linked to clock genes in all bone cells; in a small human intervention study, cumulative sleep restriction with concurrent circadian disruption negatively alter bone turnover markers in a way that could explain the lower BMD and increased fracture risk identified in some prior night shift work studies; abnormal sleep duration and obstructive sleep apnea are associated with low BMD and increased fracture risk in some but not all studies.
Normal physiology and some animal and human intervention studies suggest that sleep and circadian disruptions, such as night shift work, abnormal sleep durations and obstructive sleep apnea are detrimental to skeletal health. However, additional research in this area is needed to determine which sleep/circadian disturbances are most detrimental to skeletal health, the reversibility of such impairments, and underlying mechanisms.
本篇综述简要总结了越来越多的关于睡眠和昼夜节律紊乱对骨骼影响的文献。
该领域最新数据表明，骨转换标志物的昼夜变化是由于所有骨细胞中的时钟基因相关的内源性昼夜节律性；在一项小型人体干预研究中，累积的睡眠限制伴昼夜节律紊乱以一种可能解释一些先前夜班工作研究中发现的较低骨密度和增加骨折风险的方式改变骨转换标志物；异常的睡眠时间和阻塞性睡眠呼吸暂停与一些但不是所有研究中的低骨密度和增加骨折风险相关。
正常生理学以及一些动物和人体干预研究表明，睡眠和昼夜节律紊乱，如夜班工作、异常睡眠时间和阻塞性睡眠呼吸暂停，对骨骼健康有害。然而，需要在该领域进行更多的研究，以确定哪些睡眠/昼夜节律紊乱对骨骼健康最有害、这些损伤的可逆性以及潜在机制。
