Division of Endocrinology, Metabolism and Diabetes, University of Colorado Anschutz Medical Campus, 12801 E. 17th Ave., Mail Stop 8106, Aurora, CO, 80045, USA.
Curr Osteoporos Rep. 2022 Jun;20(3):202-212. doi: 10.1007/s11914-022-00733-y. Epub 2022 Apr 30.
Review recent literature investigating the relationship between bone health and sleep/circadian disruptions (e.g., abnormal sleep duration, night shift work).
Short and long sleep are associated with low bone mineral density (BMD). Recent data from observational studies identified an increased risk of fracture in women with short sleep. Studies suggest that age, sex, weight change, and concurrent circadian misalignment may modify the effects of sleep restriction on bone metabolism. Interventional studies demonstrate alterations in bone metabolism and structure in response to circadian disruption that could underlie the increased fracture risk seen with night shift work. The effects of sleep and circadian disruption during adolescence may have lifelong skeletal consequences if they adversely impact bone modeling. Data suggest that short sleep and night shift work negatively impact bone metabolism and health. Rigorous studies of prevalent sleep and circadian disruptions are needed to determine mechanisms and develop prevention strategies to optimize lifelong skeletal health.
回顾近期关于骨骼健康与睡眠/昼夜节律紊乱（如睡眠时间异常、倒班工作）之间关系的文献。
短时间和长时间睡眠与骨密度降低有关。来自观察性研究的最新数据表明，睡眠时间短的女性骨折风险增加。研究表明，年龄、性别、体重变化和昼夜节律失调可能会改变睡眠限制对骨代谢的影响。干预性研究表明，昼夜节律紊乱会导致骨代谢和结构发生改变，这可能是夜班工作导致骨折风险增加的原因。如果青少年时期的睡眠和昼夜节律紊乱对骨形成产生不利影响，可能会对骨骼产生终身影响。数据表明，短时间睡眠和夜班工作会对骨代谢和健康产生负面影响。需要对普遍存在的睡眠和昼夜节律紊乱进行严格研究，以确定机制并制定预防策略，从而优化终生骨骼健康。
