Jabbour Samir, Ashton Christopher, Balal Shafi, Kaye Abigail, Ahmad Sajjad
Moorfields Eye Hospital NHS Foundation Trust.
Institute of Ophthalmology, University College London, London, UK.
Curr Opin Ophthalmol. 2021 Jul 1;32(4):362-368. doi: 10.1097/ICU.0000000000000766.
The management of neurotrophic keratitis (NK) has evolved in the last decade. The present article reviews updated management guidelines of this entity, as well as future innovations in the field.
The advent of confocal microscopy has allowed for the first time to image corneal nerves. In addition, multiple novel topical treatments such as nerve growth factor have improved the prognosis of this disease, with many other in the pipeline. Finally, corneal nerve restoration is now possible with corneal neurotization procedures.
Many novel treatments based on agents that stimulate nerve regrowth are now available to treat NK. Improvement in neurotization procedures could also address advanced stages of this disease with surgery.
在过去十年中，神经营养性角膜炎（NK）的治疗方法不断发展。本文回顾了该疾病最新的治疗指南以及该领域未来的创新进展。
共聚焦显微镜的出现首次实现了对角膜神经的成像。此外，多种新型局部治疗方法，如神经生长因子，改善了该疾病的预后，还有许多其他治疗方法正在研发中。最后，通过角膜神经化手术现在可以实现角膜神经修复。
现在有许多基于刺激神经再生药物的新型治疗方法可用于治疗NK。神经化手术的改进也可以通过手术治疗该疾病的晚期阶段。
