Okuma Yu, Hirotsune Nobuyuki, Shinozaki Koichiro, Yagi Tsukasa, Kegoya Yasuhito, Sotome Yuta, Matsuda Yuki, Sato Yu, Tanabe Tomoyuki, Muraoka Kenichiro, Nishino Shigeki
Feinstein Institute for Medical Research, Northwell Health System, Manhasset, NY, USA.
Department of Neurological Surgery, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan.
Adv Exp Med Biol. 2021;1269:63-67. doi: 10.1007/978-3-030-48238-1_10.
Cerebral hyperperfusion syndrome (CHS) is a rare but fatal perioperative complication after surgical correction of carotid stenosis. Despite numerous treatment options for preventing CHS, it does occur in some patients. We developed the outlet gate technique (OGT), in which the embolic balloon was deflated gradually in accordance with the ratio of oxygen saturation measured by a brain oximeter of the ipsilateral brain region to that in the contralateral region. Between June 2017 and May 2018, 39 patients with carotid stenosis underwent endovascular carotid revascularization procedures; of these, 20 underwent the procedure with the OGT. CBO was measured five times in those 20 patients: before the procedure, with the embolic protection device (EPD) on, with the EPD off, during the procedure, and after the procedure. Preventive treatment options were used more frequently in these patients, and although their surgical status seemed more complicated, perioperative complications were not increased. There were almost significant differences between CBO values except between those during and after the procedure with the OGT. This showed that the OGT allowed for stabilization of the CBO and thus has the potential to prevent CHS.
大脑高灌注综合征(CHS)是颈动脉狭窄手术后罕见但致命的围手术期并发症。尽管有许多预防 CHS 的治疗选择,但一些患者仍会发生 CHS。我们开发了出口门技术(OGT),其中根据脑氧计测量的同侧脑区与对侧脑区的氧饱和度比,逐渐放气栓塞球囊。2017 年 6 月至 2018 年 5 月,39 例颈动脉狭窄患者接受了血管内颈动脉血运重建术;其中 20 例采用 OGT 进行治疗。在这 20 例患者中,CBO 被测量了五次:手术前、放置栓塞保护装置(EPD)时、EPD 取下时、手术过程中和手术后。这些患者更频繁地使用了预防性治疗选择,尽管他们的手术情况似乎更复杂,但围手术期并发症并未增加。除了 OGT 术中与术后的 CBO 值外,其他值之间几乎存在显著差异。这表明 OGT 可以稳定 CBO,从而有可能预防 CHS。