大鼠再生和移植骨骼肌中的卫星细胞。

Satellite cells in the regenerated and regrafted skeletal muscles of rats.

作者信息

Mong F S

机构信息

Department of Anatomical Sciences, University of Texas, Dental Branch, Houston 77225.

出版信息

Experientia. 1988 Jul 15;44(7):601-3. doi: 10.1007/BF01953309.

DOI:10.1007/BF01953309

PMID:3396655

Abstract

Soleus (SOL) muscles were grafted into extensor digitorum longus (EDL) muscle beds (EDL-first-graft). Sixty days later, some mature EDL-first-grafts were regrafted into their own beds (EDL-second-grafts). Fully regenerated muscle fibers and satellite cells were observed in both types of mature grafts. The ratios of satellite cell nuclei per total nuclei (myonuclei and satellite cell nuclei) were 4.81 +/- 0.47% for EDL-2nd graft, 4.26 +/- 0.51% for EDL-1st-graft, 4.30 +/- 0.33% for control SOL, and 3.30 +/- 0.18% for control EDL. It is thought that satellite cells are required for the repeated activity of muscle fiber regeneration. The persistance of satellite cells in EDL-second-grafts suggests that satellite cells are not depleted during the first grafting, making second-grafts possible.

摘要

将比目鱼肌（SOL）移植到趾长伸肌（EDL）肌床中（EDL首次移植）。60天后，将一些成熟的EDL首次移植体重新移植回其自身的肌床中（EDL二次移植）。在两种类型的成熟移植体中均观察到完全再生的肌纤维和卫星细胞。EDL二次移植体中卫星细胞核占总细胞核（肌细胞核和卫星细胞核）的比例为4.81±0.47%，EDL首次移植体为4.26±0.51%，对照比目鱼肌为4.30±0.33%，对照趾长伸肌为3.30±0.18%。据认为，卫星细胞是肌纤维再生重复活动所必需的。EDL二次移植体中卫星细胞的持续存在表明卫星细胞在首次移植过程中未被耗尽，从而使得二次移植成为可能。