Department of Radiation Oncology, The First Hospital of China Medical University, Shenyang, China.
Department of Neurosurgery, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Cell Cycle. 2021 Jun;20(11):1091-1106. doi: 10.1080/15384101.2021.1922160. Epub 2021 May 9.
Mismatch repair (MMR) plays an important role in the occurrence and development of tumors. At present, it is widely believed that MMR is a protective mechanism of tumors that plays a critical role in the progresses of cancer. In this study, 34 genes related to MMR selected from Gene Ontology (GO) database were scored by single sample Gene sets enrichment analysis (ssGSEA), and eight cancers were screened from 23 TCGA solid cancers to investigate the clinical significance of MMR score. MMR had different effects on the prognosis of the eight tumors, with a protective effect in three cancers and functioning as a risk factor in the remaining five cancers. We used unsupervised clustering to divide the patients into four clusters. We found that the immune and metabolic status of the four clusters were extremely different, among which cluster1 had the lowest tumor purity and the most complex microenvironment; this may explain its poor prognosis and immunotherapy effect. In summary, MMR scores can improve the predictive ability and provide effective guidance for immunotherapy in individual type of tumors.
错配修复（MMR）在肿瘤的发生和发展中起着重要作用。目前，广泛认为 MMR 是肿瘤的一种保护机制，在癌症的进展中起着关键作用。在这项研究中，从基因本体论（GO）数据库中选择了 34 个与 MMR 相关的基因，通过单样本基因集富集分析（ssGSEA）进行评分，并从 23 种 TCGA 实体瘤中筛选出 8 种癌症，以研究 MMR 评分的临床意义。MMR 对 8 种肿瘤的预后有不同的影响，在 3 种肿瘤中具有保护作用，而在其余 5 种肿瘤中则作为危险因素发挥作用。我们使用无监督聚类将患者分为 4 个聚类。我们发现，这四个聚类的免疫和代谢状态差异极大，其中聚类 1 的肿瘤纯度最低，微环境最复杂；这可能解释了其预后不良和免疫治疗效果不佳。总之，MMR 评分可以提高预测能力，并为个体类型的肿瘤的免疫治疗提供有效指导。
