Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine and Alzheimer's Disease and Related Disorders Center, Shanghai Jiao Tong University, Shanghai, China.
Int Psychogeriatr. 2023 Aug;35(8):439-448. doi: 10.1017/S1041610221000466. Epub 2021 May 10.
To examine the association between sleep duration in different stages of life and amnestic mild cognitive impairment (aMCI).
DESIGN, SETTING, AND PARTICIPANTS: A total of 2472 healthy elderly and 505 patients with aMCI in China were included in this study. The study analyzed the association between aMCI and sleep duration in different stages of life.
We compared sleep duration in different stages of life and analyzed the association between Montreal Cognitive Assessment scores and sleep duration by curve estimation. Logistic regression was used to evaluate the association between aMCI and sleep duration.
In the analysis, there were no results proving that sleep duration in youth ( = 0.719, sleep duration < 10 hours; = 0.999, sleep duration ≥ 10 hours) or midlife ( = 0.898, sleep duration < 9 hours; = 0.504, sleep duration ≥ 9 hours) had a significant association with aMCI. In the group sleeping less than 7 hours in late life, each hour more of sleep duration was associated with approximately 0.80 of the original risk of aMCI ( = 0.011, odds ratio = 0.80, 95% confidence interval = 0.68-0.95).
Among the elderly sleeping less than 7 hours, there is a decreased risk of aMCI for every additional hour of sleep.
探讨不同生命阶段的睡眠时间与遗忘型轻度认知障碍（aMCI）的关系。
设计、地点和参与者：本研究共纳入中国 2472 名健康老年人和 505 名 aMCI 患者。该研究分析了 aMCI 与不同生命阶段睡眠时间的关系。
我们比较了不同生命阶段的睡眠时间，并通过曲线估计分析了蒙特利尔认知评估评分与睡眠时间之间的关系。使用 logistic 回归评估 aMCI 与睡眠时间之间的关系。
在分析中，没有结果证明青年期（ = 0.719，睡眠时间<10 小时； = 0.999，睡眠时间≥10 小时）或中年期（ = 0.898，睡眠时间<9 小时； = 0.504，睡眠时间≥9 小时）的睡眠时间与 aMCI 有显著关联。在晚年睡眠时间少于 7 小时的人群中，每增加一小时睡眠时间，aMCI 的原始风险约降低 0.80（ = 0.011，比值比=0.80，95%置信区间=0.68-0.95）。
在睡眠时间少于 7 小时的老年人中，每增加一小时睡眠时间，aMCI 的风险就会降低。
