Halinen M O, Hakumäki M O, Sarajas H S
Acta Physiol Scand. 1977 Nov;101(3):264-9. doi: 10.1111/j.1748-1716.1977.tb06007.x.
Cardiovascular and autonomic nervous responses to an injection of E. coli endotoxin were followed for up to 15 min. in cats anesthetized with chloralose and given artificial respiration. Within 60 seconds, endotoxin induced a drop of aortic pressure, with simultaneous cardiac acceleration and slight central venous hypertension. There was an associated, almost complete cessation of the aortic arch baroreceptor afferentation. The cardiac sympathetic efferentation increased up to 1.4 times the control level at its maximum. The splenic sympathetic efferentation increased up to 10.6 times the control level at the end of the 15 min period, when the other parameters studied showed a trend to control level. The sympathetic autonomic system seems to be activated through cardiovascular receptors sensing hemodynamic changes touched off by endotoxin-induced release of vasoactive substances.
在用氯醛糖麻醉并进行人工呼吸的猫身上，观察了注射大肠杆菌内毒素后长达15分钟的心血管和自主神经反应。在60秒内，内毒素导致主动脉压下降，同时伴有心脏加速和轻微的中心静脉高压。伴有主动脉弓压力感受器传入几乎完全停止。心脏交感神经传出在最大值时增加到对照水平的1.4倍。在15分钟期末，脾交感神经传出增加到对照水平的10.6倍，此时所研究的其他参数显示出恢复到对照水平的趋势。交感自主神经系统似乎是通过感知内毒素诱导的血管活性物质释放所引发的血流动力学变化的心血管受体而被激活的。
