新型线性环化三环化合物作为刚性多巴胺类似物的合成。
Synthesis of new linearly annulated tricycles as rigid dopamine congeners.
作者信息
Perrone R, Berardi F, Bettoni G, Tortorella V
机构信息
Dipartimento Farmacochimico, Università di Bari, Italy.
出版信息
Farmaco Sci. 1988 Jan;43(1):71-7. doi: 10.1002/chin.198834196.
PMID:3396690
Abstract
A simple synthetic route that leads to three isosters of octahydrobenzo[g]quinolines (IA), in which the carbon atom in 4-position is replaced by an oxygen, a sulfur or a nitrogen atom, to give hexahydronaphth-[1,4]oxazine (VIII a) and -[1,4]thiazine (VIII b), and octahydrobenzo[g]quinoxaline (VIII c) respectively, is here reported. These compounds can be considered as new structural models of dopamine agonists.
摘要
本文报道了一条简单的合成路线，该路线可得到八氢苯并[g]喹啉（IA）的三种电子等排体，其中4位的碳原子分别被氧、硫或氮原子取代，分别得到六氢萘并[1,4]恶嗪（VIII a）、- [1,4]噻嗪（VIII b）和八氢苯并[g]喹喔啉（VIII c）。这些化合物可被视为多巴胺激动剂的新结构模型。
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