Fujimoto Yuji, Hashimoto Masayoshi, Yamaji Yasuyuki
Department of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, The University of Tokyo.
Uirusu. 2020;70(1):61-68. doi: 10.2222/jsv.70.61.
Plant viruses, obligate parasitic pathogens, utilize a variety of host plant factors in the process of their infection due to the limited number of genes encoded in their own genomes. The genes encoding these host factors are called susceptibility genes because they are responsible for the susceptibility of plants to viruses. Plants lacking or having mutations in a susceptibility gene essential for the infection of a virus acquire resistance to the virus. Such resistance trait is called recessive resistance because of the recessive inherited characteristics. Recessive resistance is reported to account for about half of the plant viral resistance loci mapped in known cultivated crops. Eukaryotic translation initiation factor (eIF) 4E family genes are well-known susceptibility genes. Although there are many reports about eIF4E-mediated recessive resistance to plant viruses, the mechanistic insight of the resistance is still limited. Here we review focusing on studies that have elucidated the mechanism of eIF4E-mediated recessive resistance.
植物病毒是专性寄生病原体，由于其自身基因组中编码的基因数量有限，在感染过程中会利用多种宿主植物因子。编码这些宿主因子的基因被称为感病基因，因为它们决定了植物对病毒的易感性。对于某种病毒感染必不可少的感病基因缺失或发生突变的植物，会获得对该病毒的抗性。由于这种抗性性状具有隐性遗传特征，所以被称为隐性抗性。据报道，隐性抗性约占已知栽培作物中已定位的植物病毒抗性位点的一半。真核翻译起始因子（eIF）4E家族基因是众所周知的感病基因。尽管有许多关于eIF4E介导的植物病毒隐性抗性的报道，但对其抗性机制的深入了解仍然有限。在此，我们重点综述了阐明eIF4E介导的隐性抗性机制的研究。
