Southern Crop Protection and Food Research Centre, Agriculture and Agri-Food Canada, London, ON, Canada, N5V 4T3.
Mol Plant Pathol. 2012 Sep;13(7):795-803. doi: 10.1111/j.1364-3703.2012.00791.x. Epub 2012 Mar 2.
The use of genetic resistance is considered to be the most effective and sustainable approach to the control of plant pathogens. Although most of the known natural resistance genes are monogenic dominant R genes that are predominant against fungi and bacteria, more and more recessive resistance genes against viruses have been cloned in the last decade. Interestingly, of the 14 natural recessive resistance genes against plant viruses that have been cloned from diverse plant species thus far, 12 encode the eukaryotic translation initiation factor 4E (eIF4E) or its isoform eIF(iso)4E. This review is intended to summarize the current state of knowledge about eIF4E and the possible mechanisms underlying its essential role in virus infection, and to discuss recent progress and the potential of eIF4E as a target gene in the development of genetic resistance to viruses for crop improvement.
利用遗传抗性被认为是控制植物病原体最有效和最可持续的方法。虽然大多数已知的天然抗性基因是针对真菌和细菌的显性单基因 R 基因，但在过去十年中，越来越多的针对病毒的隐性抗性基因被克隆出来。有趣的是，迄今为止，从不同植物物种中克隆的 14 个针对植物病毒的天然隐性抗性基因中，有 12 个编码真核翻译起始因子 4E(eIF4E)或其同工型 eIF(iso)4E。本文旨在总结目前关于 eIF4E 的知识状况及其在病毒感染中基本作用的可能机制，并讨论最近的进展以及将 eIF4E 作为目标基因用于遗传抗性开发以改善作物对病毒的抗性的潜力。
