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抗反流手术的术前食管生理学评估:高分辨率测压和 pH 测试对外科医生的指导。

Preoperative physiological esophageal assessment for anti-reflux surgery: A guide for surgeons on high-resolution manometry and pH testing.

机构信息

Department of Gastroenterology, Albany Medical College, Albany, NY 12208, United States.

Section of Gastroenterology, Stratton VA Medical Center, Albany, NY 12208, United States.

出版信息

World J Gastroenterol. 2021 Apr 28;27(16):1751-1769. doi: 10.3748/wjg.v27.i16.1751.


DOI:10.3748/wjg.v27.i16.1751
PMID:33967555
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8072189/
Abstract

Gastroesophageal reflux disease (GERD) is one of the most commonly encountered digestive diseases in the world, with the prevalence continuing to increase. Many patients are successfully treated with lifestyle modifications and proton pump inhibitor therapy, but a subset of patients require more aggressive intervention for control of their symptoms. Surgical treatment with fundoplication is a viable option for patients with GERD, as it attempts to improve the integrity of the lower esophageal sphincter (LES). While surgery can be as effective as medical treatment, it can also be associated with side effects such as dysphagia, bloating, and abdominal pain. Therefore, a thorough pre-operative assessment is crucial to select appropriate surgical candidates. Newer technologies are becoming increasingly available to help clinicians identify patients with true LES dysfunction, such as pH-impedance studies and high-resolution manometry (HRM). Pre-operative evaluation should be aimed at confirming the diagnosis of GERD, ruling out any major motility disorders, and selecting appropriate surgical candidates. HRM and pH testing are key tests to consider for patients with GERD like symptoms, and the addition of provocative measures such as straight leg raises and multiple rapid swallows to HRM protocol can assess the presence of underlying hiatal hernias and to test a patient's peristaltic reserve prior to surgery.

摘要

胃食管反流病(GERD)是世界上最常见的消化系统疾病之一,其患病率持续上升。许多患者通过生活方式改变和质子泵抑制剂治疗得到了成功治疗,但一部分患者需要更积极的干预措施来控制症状。胃底折叠术是 GERD 患者的一种可行治疗选择,因为它试图改善下食管括约肌(LES)的完整性。虽然手术可以像药物治疗一样有效,但也可能会出现副作用,如吞咽困难、腹胀和腹痛。因此,术前全面评估对于选择合适的手术患者至关重要。新技术越来越多地用于帮助临床医生识别真正的 LES 功能障碍患者,如 pH 阻抗研究和高分辨率测压(HRM)。术前评估的目的应在于确认 GERD 的诊断,排除任何主要的运动障碍,并选择合适的手术患者。对于有 GERD 样症状的患者,HRM 和 pH 测试是关键的考虑因素,并且可以在 HRM 方案中添加直腿抬高和多次快速吞咽等激发措施,以评估潜在的食管裂孔疝,并在手术前测试患者的蠕动储备。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b410/8072189/d1329a3ecba5/WJG-27-1751-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b410/8072189/47c9a2be6aab/WJG-27-1751-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b410/8072189/7f70a2876dbe/WJG-27-1751-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b410/8072189/1f8d62c9230d/WJG-27-1751-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b410/8072189/388b8d8c6e6c/WJG-27-1751-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b410/8072189/ea922a74d331/WJG-27-1751-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b410/8072189/ab30e72e74a2/WJG-27-1751-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b410/8072189/3e3c430e12b9/WJG-27-1751-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b410/8072189/d1329a3ecba5/WJG-27-1751-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b410/8072189/c714303856e5/WJG-27-1751-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b410/8072189/a08c651869ec/WJG-27-1751-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b410/8072189/47c9a2be6aab/WJG-27-1751-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b410/8072189/7f70a2876dbe/WJG-27-1751-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b410/8072189/1f8d62c9230d/WJG-27-1751-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b410/8072189/388b8d8c6e6c/WJG-27-1751-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b410/8072189/ea922a74d331/WJG-27-1751-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b410/8072189/ab30e72e74a2/WJG-27-1751-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b410/8072189/3e3c430e12b9/WJG-27-1751-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b410/8072189/d1329a3ecba5/WJG-27-1751-g012.jpg

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本文引用的文献

[1]
Esophageal Motility Disorders and Gastroesophageal Reflux Disease.

N Engl J Med. 2020-11-12

[2]
Patterns of esophageal dysmotility elicited by multiple rapid swallows.

Esophagus. 2021-4

[3]
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Am J Gastroenterol. 2020-9

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Dysphagia. 2021-6

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Obes Surg. 2021-1

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Curr Opin Gastroenterol. 2020-7

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Identification of Different Phenotypes of Esophageal Reflux Hypersensitivity and Implications for Treatment.

Clin Gastroenterol Hepatol. 2021-4

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Trans-esophagogastric junction pressure gradients during straight leg raise maneuver on high-resolution manometry associate with large hiatus hernias.

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Role and safety of fundoplication in esophageal disease and dysmotility syndromes.

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