Li Qipeng, Yin Qiuxiang, Hou Baohong, Zhou Ling
School of Chemical Engineering and Technology, Tianjin University, Tianjin, P. R. China.
Des Monomers Polym. 2021 Apr 22;24(1):106-112. doi: 10.1080/15685551.2021.1919389.
Implanted medical devices that have poor friction property or biofilm formation can limit their service life and cause discomfort in patients. Recently, some zwitterionic coatings have been studied to modify the biomaterials surface for lubricating function, but the grafting methods of coatings are complicated and also seldom take the bacterial antiadhesion property into account at the same time. In our studies, motivated by the properties of nature mussels and human articular, we firstly successfully synthesized double adhesion protection of self-adhesive ternary polymer coating and achieved the excellent lubrication and antifouling functionalization of the medical devices surface. In details, the X-ray photoelectron spectroscopy, scanning electron microscope and the water contact angles could characterize the successful modification on the surface of titanium substrate. Additionally, the tribological tests carried out by atomic force microscope verified the ternary polymer could enhance the lubrication property owing to the hydration lubrication mechanism. Meanwhile, it also possessed the bacterial antiadhesion property for the initial 24 h attributed to the hydration repulsive force. We believe that, as a simple and universal preparation method, the ternary polymer could make a great significance for improving the surface function of biomaterials and alleviating patients' discomfort.
摩擦性能差或易形成生物膜的植入式医疗设备会限制其使用寿命，并给患者带来不适。最近，一些两性离子涂层被研究用于修饰生物材料表面以实现润滑功能，但涂层的接枝方法复杂，且很少同时考虑细菌抗粘附性能。在我们的研究中，受天然贻贝和人体关节特性的启发，我们首先成功合成了具有自粘性的三元聚合物涂层的双重粘附保护，并实现了医疗设备表面优异的润滑和防污功能化。具体而言，X射线光电子能谱、扫描电子显微镜和水接触角可以表征钛基底表面的成功改性。此外，原子力显微镜进行的摩擦学测试证实，由于水合润滑机制，三元聚合物可以增强润滑性能。同时，由于水合排斥力，它在最初24小时内也具有细菌抗粘附性能。我们认为，作为一种简单通用的制备方法，三元聚合物对于改善生物材料的表面功能和减轻患者不适具有重要意义。
