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银纳米粒子的潜在抗菌机制及先进改性技术在骨科植入物优化方面的应用。

Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies.

机构信息

Orthopaedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, People's Republic of China.

Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun 130041, People's Republic of China.

出版信息

Int J Nanomedicine. 2018 Jun 5;13:3311-3327. doi: 10.2147/IJN.S165125. eCollection 2018.

DOI:10.2147/IJN.S165125
PMID:29892194
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5993028/
Abstract

Infection, as a common postoperative complication of orthopedic surgery, is the main reason leading to implant failure. Silver nanoparticles (AgNPs) are considered as a promising antibacterial agent and always used to modify orthopedic implants to prevent infection. To optimize the implants in a reasonable manner, it is critical for us to know the specific antibacterial mechanism, which is still unclear. In this review, we analyzed the potential antibacterial mechanisms of AgNPs, and the influences of AgNPs on osteogenic-related cells, including cellular adhesion, proliferation, and differentiation, were also discussed. In addition, methods to enhance biocompatibility of AgNPs as well as advanced implants modifications technologies were also summarized.

摘要

感染是骨科手术后常见的并发症，是导致植入物失败的主要原因。纳米银颗粒（AgNPs）被认为是一种有前途的抗菌剂，常用于修饰骨科植入物以预防感染。为了以合理的方式优化植入物，了解其具体的抗菌机制至关重要，但目前这一机制尚不清楚。在本综述中，我们分析了 AgNPs 的潜在抗菌机制，并讨论了 AgNPs 对成骨相关细胞的影响，包括细胞黏附、增殖和分化。此外，还总结了提高 AgNPs 生物相容性的方法和先进的植入物修饰技术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c6e/5993028/f4a7bb8afef5/ijn-13-3311Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c6e/5993028/3363ae72feb6/ijn-13-3311Fig1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c6e/5993028/6c80af31f0ac/ijn-13-3311Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c6e/5993028/f4a7bb8afef5/ijn-13-3311Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c6e/5993028/3363ae72feb6/ijn-13-3311Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c6e/5993028/7fa47e1c7275/ijn-13-3311Fig2.jpg
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