• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

低温对窒息性心脏骤停后大鼠肝脏炎症细胞因子表达的影响。

Effects of hypothermia on inflammatory cytokine expression in rat liver following asphyxial cardiac arrest.

作者信息

Park Yoonsoo, Ahn Ji Hyeon, Cho Jeong Hwi, Tae Hyun-Jin, Lee Tae-Kyeong, Kim Bora, Lee Jae-Chul, Park Joon Ha, Shin Myoung Cheol, Ohk Taek Geun, Cho Jun Hwi, Won Moo-Ho

机构信息

Department of Emergency Medicine, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, Gangwon 24289, Republic of Korea.

Department of Physical Therapy, College of Health Science, Youngsan University, Yangsan, Gyeongnam 50510, Republic of Korea.

出版信息

Exp Ther Med. 2021 Jun;21(6):626. doi: 10.3892/etm.2021.10058. Epub 2021 Apr 15.

DOI:10.3892/etm.2021.10058
PMID:33968162
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8097226/
Abstract

Hypothermic treatment is known to protect against cardiac arrest (CA) and improve survival rate. However, few studies have evaluated the CA-induced liver damage and the effects of hypothermia on this damage. Therefore, the aim of the present study was to determine possible protective effects of hypothermia on the liver after asphyxial CA. Rats were subjected to a 5-min asphyxial CA followed by return of spontaneous circulation (ROSC). The body temperature was controlled at 37±0.5˚C (normothermia group) or 33±0.5˚C (hypothermia group) for 4 h after ROSC. Livers were examined at 6, 12 h, 1 and 2 days after ROSC. Histopathological examination was performed by H&E staining. Alterations in the expression levels of pro-inflammatory (TNF-α and interleukin IL-2) and anti-inflammatory cytokines (IL-4 and IL-13) were investigated by immunohistochemistry. Sinusoidal dilatation and vacuolization were observed after asphyxial CA by histopathological examination. However, these CA-induced structural alterations were prevented by hypothermia. In immunohistochemical examination, the expression levels of pro-inflammatory cytokines were reduced in the hypothermia group compared with those in the normothermia group while the expression levels of anti-inflammatory cytokines were increased in the hypothermia group compared with those in the normothermia group. In conclusion, hypothermic treatment for 4 h following asphyxial CA in rats inhibited the increase of pro-inflammatory cytokines and stimulated the expression of anti-inflammatory cytokines compared with the normothermic group. The results of the present study suggested that hypothermic treatment after asphyxial CA reduced liver damage via the regulation of inflammation.

摘要

已知低温治疗可预防心脏骤停（CA）并提高生存率。然而，很少有研究评估CA诱导的肝损伤以及低温对这种损伤的影响。因此，本研究的目的是确定低温对窒息性CA后肝脏的可能保护作用。将大鼠进行5分钟的窒息性CA，随后恢复自主循环（ROSC）。ROSC后4小时将体温控制在37±0.5˚C（正常体温组）或33±0.5˚C（低温组）。在ROSC后6、12小时、1天和2天检查肝脏。通过苏木精-伊红（H&E）染色进行组织病理学检查。通过免疫组织化学研究促炎细胞因子（TNF-α和白细胞介素IL-2）和抗炎细胞因子（IL-4和IL-13）表达水平的变化。组织病理学检查观察到窒息性CA后出现肝血窦扩张和空泡化。然而，低温可预防这些CA诱导的结构改变。在免疫组织化学检查中，与正常体温组相比，低温组促炎细胞因子的表达水平降低，而抗炎细胞因子的表达水平升高。总之，与正常体温组相比，大鼠窒息性CA后进行4小时的低温治疗可抑制促炎细胞因子的增加并刺激抗炎细胞因子的表达。本研究结果表明，窒息性CA后进行低温治疗可通过调节炎症减轻肝损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a1/8097226/fb5f92e6fc44/etm-21-06-10058-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a1/8097226/e5be336a65dd/etm-21-06-10058-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a1/8097226/d780850e201f/etm-21-06-10058-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a1/8097226/384a69c8b286/etm-21-06-10058-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a1/8097226/f6871c3bb29d/etm-21-06-10058-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a1/8097226/fb5f92e6fc44/etm-21-06-10058-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a1/8097226/e5be336a65dd/etm-21-06-10058-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a1/8097226/d780850e201f/etm-21-06-10058-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a1/8097226/384a69c8b286/etm-21-06-10058-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a1/8097226/f6871c3bb29d/etm-21-06-10058-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93a1/8097226/fb5f92e6fc44/etm-21-06-10058-g04.jpg

相似文献

1
Effects of hypothermia on inflammatory cytokine expression in rat liver following asphyxial cardiac arrest.低温对窒息性心脏骤停后大鼠肝脏炎症细胞因子表达的影响。
Exp Ther Med. 2021 Jun;21(6):626. doi: 10.3892/etm.2021.10058. Epub 2021 Apr 15.
2
Hypothermic treatment reduces matrix metalloproteinase-9 expression and damage in the liver following asphyxial cardiac arrest in rats.低温治疗可降低大鼠窒息性心脏骤停后肝脏中基质金属蛋白酶-9的表达及损伤。
Lab Anim Res. 2021 Jul 14;37(1):16. doi: 10.1186/s42826-021-00095-z.
3
Therapeutic Hypothermia after Cardiac Arrest Attenuates Hindlimb Paralysis and Damage of Spinal Motor Neurons and Astrocytes through Modulating Nrf2/HO-1 Signaling Pathway in Rats.心肺复苏后治疗性低温通过调节 Nrf2/HO-1 信号通路减轻大鼠后肢瘫痪和脊髓运动神经元及星形胶质细胞损伤。
Cells. 2023 Jan 26;12(3):414. doi: 10.3390/cells12030414.
4
Therapeutic hypothermia reduces inflammation and oxidative stress in the liver after asphyxial cardiac arrest in rats.治疗性低温可减轻大鼠窒息性心脏骤停后肝脏的炎症和氧化应激。
Acute Crit Care. 2020 Nov;35(4):286-295. doi: 10.4266/acc.2020.00304. Epub 2020 Nov 30.
5
Protective effects of therapeutic hypothermia on renal injury in an asphyxial cardiac arrest rat model.亚低温对窒息性心脏骤停大鼠模型肾损伤的保护作用。
J Therm Biol. 2020 Dec;94:102761. doi: 10.1016/j.jtherbio.2020.102761. Epub 2020 Oct 13.
6
HSP70-mediated neuroprotection by combined treatment of valproic acid with hypothermia in a rat asphyxial cardiac arrest model.HSP70 介导的丙戊酸联合低温治疗对窒息性心跳骤停大鼠的神经保护作用。
PLoS One. 2021 Jun 17;16(6):e0253328. doi: 10.1371/journal.pone.0253328. eCollection 2021.
7
Effects of regional body temperature variation during asphyxial cardiac arrest on mortality and brain damage in a rat model.窒息性心脏骤停期间区域性体温变化对大鼠模型死亡率和脑损伤的影响。
J Therm Biol. 2020 Jan;87:102466. doi: 10.1016/j.jtherbio.2019.102466. Epub 2019 Nov 26.
8
The effect of mild hypothermia and induced hypertension on long term survival rate and neurological outcome after asphyxial cardiac arrest in rats.轻度低温和诱导性高血压对大鼠窒息性心脏骤停后长期存活率和神经功能结局的影响。
Resuscitation. 2001 Apr;49(1):73-82. doi: 10.1016/s0300-9572(00)00268-9.
9
Effect of therapeutic hypothermia against renal injury in a rat model of asphyxial cardiac arrest: Α focus on the survival rate, pathophysiology and antioxidant enzymes.治疗性低体温对窒息性心脏骤停大鼠模型肾损伤的影响：关注存活率、病理生理学和抗氧化酶。
Mol Med Rep. 2022 Jan;25(1). doi: 10.3892/mmr.2021.12535. Epub 2021 Nov 19.
10
Therapeutic hypothermia attenuates paraplegia and neuronal damage in the lumbar spinal cord in a rat model of asphyxial cardiac arrest.亚低温治疗减轻窒息性心跳骤停大鼠模型中脊髓损伤和神经元损伤。
J Therm Biol. 2019 Jul;83:1-7. doi: 10.1016/j.jtherbio.2019.04.018. Epub 2019 Apr 30.

引用本文的文献

1
Risperidone Administration Attenuates Renal Ischemia and Reperfusion Injury following Cardiac Arrest by Antiinflammatory Effects in Rats.利培酮给药通过抗炎作用减轻大鼠心脏骤停后的肾缺血再灌注损伤。
Vet Sci. 2023 Feb 28;10(3):184. doi: 10.3390/vetsci10030184.
2
Anti-Inflammatory CDGSH Iron-Sulfur Domain 2: A Biomarker of Central Nervous System Insult in Cellular, Animal Models and Patients.抗炎性CDGSH铁硫结构域2：细胞、动物模型及患者中枢神经系统损伤的生物标志物
Biomedicines. 2022 Mar 27;10(4):777. doi: 10.3390/biomedicines10040777.
3
Effect of therapeutic hypothermia against renal injury in a rat model of asphyxial cardiac arrest: Α focus on the survival rate, pathophysiology and antioxidant enzymes.

本文引用的文献

1
Effects of regional body temperature variation during asphyxial cardiac arrest on mortality and brain damage in a rat model.窒息性心脏骤停期间区域性体温变化对大鼠模型死亡率和脑损伤的影响。
J Therm Biol. 2020 Jan;87:102466. doi: 10.1016/j.jtherbio.2019.102466. Epub 2019 Nov 26.
2
Therapeutic Hypothermia Improves Hind Limb Motor Outcome and Attenuates Oxidative Stress and Neuronal Damage in the Lumbar Spinal Cord Following Cardiac Arrest.治疗性低温可改善心脏骤停后后肢运动结果，并减轻腰段脊髓的氧化应激和神经元损伤。
Antioxidants (Basel). 2020 Jan 1;9(1):38. doi: 10.3390/antiox9010038.
3
Effects of the duration of postresuscitation hyperoxic ventilation on neurological outcome and survival in an asphyxial cardiac arrest rat model.
治疗性低体温对窒息性心脏骤停大鼠模型肾损伤的影响：关注存活率、病理生理学和抗氧化酶。
Mol Med Rep. 2022 Jan;25(1). doi: 10.3892/mmr.2021.12535. Epub 2021 Nov 19.
4
Therapeutic hypothermia effect on asphyxial cardiac arrest-induced renal ischemia/reperfusion injury via change of Nrf2/HO-1 levels.治疗性低温通过改变Nrf2/HO-1水平对窒息性心脏骤停诱导的肾缺血/再灌注损伤的影响。
Exp Ther Med. 2021 Sep;22(3):1031. doi: 10.3892/etm.2021.10463. Epub 2021 Jul 18.
再灌注后高氧通气时间对窒息性心跳骤停大鼠模型神经功能结局和存活率的影响。
Sci Rep. 2019 Nov 11;9(1):16500. doi: 10.1038/s41598-019-52477-y.
4
Therapeutic hypothermia attenuates paraplegia and neuronal damage in the lumbar spinal cord in a rat model of asphyxial cardiac arrest.亚低温治疗减轻窒息性心跳骤停大鼠模型中脊髓损伤和神经元损伤。
J Therm Biol. 2019 Jul;83:1-7. doi: 10.1016/j.jtherbio.2019.04.018. Epub 2019 Apr 30.
5
Melatonin alleviates asphyxial cardiac arrest-induced cerebellar Purkinje cell death by attenuation of oxidative stress.褪黑素通过减轻氧化应激缓解窒息性心跳骤停诱导的小脑浦肯野细胞死亡。
Exp Neurol. 2019 Oct;320:112983. doi: 10.1016/j.expneurol.2019.112983. Epub 2019 Jun 26.
6
Mild hypothermia pretreatment protects against liver ischemia reperfusion injury via the PI3K/AKT/FOXO3a pathway.轻度低温预处理通过 PI3K/AKT/FOXO3a 通路保护肝脏缺血再灌注损伤。
Mol Med Rep. 2017 Nov;16(5):7520-7526. doi: 10.3892/mmr.2017.7501. Epub 2017 Sep 18.
7
PRELIMINARY RESULTS OF TOPICAL HEPATIC HYPOTHERMIA IN A MODEL OF LIVER ISCHEMIA/REPERFUSION INJURY IN RATS.大鼠肝脏缺血/再灌注损伤模型中局部肝脏低温治疗的初步结果
Arq Gastroenterol. 2017 Jul-Sept;54(3):246-249. doi: 10.1590/S0004-2803.201700000-30. Epub 2017 Jul 6.
8
Hepatic ischemia reperfusion injury: A systematic review of literature and the role of current drugs and biomarkers.肝缺血再灌注损伤：文献系统评价及现有药物和生物标志物的作用。
Int J Surg. 2016 Sep;33 Suppl 1:S57-70. doi: 10.1016/j.ijsu.2016.05.050. Epub 2016 May 30.
9
Post-resuscitation care following out-of-hospital and in-hospital cardiac arrest.院外和院内心脏骤停后的复苏后护理。
Heart. 2015 Dec;101(24):1943-9. doi: 10.1136/heartjnl-2015-307450. Epub 2015 Sep 18.
10
Therapeutic Hypothermia in Deceased Organ Donors and Kidney-Graft Function.《器官捐献者的治疗性低温与肾移植功能》
N Engl J Med. 2015 Jul 30;373(5):405-14. doi: 10.1056/NEJMoa1501969.