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[参与雄性小鼠罗伯逊易位的第2和第6号染色体上交叉的分布情况]

[Distribution of chiasmas in the 2d and 6th chromosomes involved in Robertsonian translocations in male mice].

作者信息

Gorlov I P

出版信息

Genetika. 1988 Apr;24(4):641-7.

PMID:3396871
Abstract

The distribution of chiasmata in 2 and 6 chromosomes in males homozygous for Rb(2.6)4Iem and Rb(8.17)1Iem was studied. Chiasmata were shown to distribute along chromosomes non-randomly, exchanges occurring in telomeric regions. Chiasmata distribution is substantially different for the cases of one and two chiasmata per bivalent. The main cause for these differences is supposed to be strong positive chiasmata interference (the position of the first chiasma may determine the position of the second one). The centromere blocks this effect, so chiasma in one arm does not interfere with that in the second arm. It has been shown that the frequency of double exchanges depended on not only the distance between markers under study, but also on marker position in the chromosome.

摘要

对Rb(2.6)4Iem和Rb(8.17)1Iem纯合子雄性个体中2号和6号染色体上交叉的分布进行了研究。结果表明交叉沿染色体呈非随机分布,交换发生在端粒区域。每个二价体有一个和两个交叉的情况,交叉分布存在显著差异。这些差异的主要原因被认为是强烈的正交叉干涉(第一个交叉的位置可能决定第二个交叉的位置)。着丝粒会阻止这种效应,所以一条臂上的交叉不会干扰另一条臂上的交叉。研究表明,双交换的频率不仅取决于所研究标记之间的距离,还取决于标记在染色体上的位置。

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