通过比较遗传图谱和交叉分布对小鼠染色体上的基因进行定位
[Localization of genes on mouse chromosomes by comparing the genetic map and chiasma distribution].
作者信息
Gorlov I P, Agul'nik A I, Agul'nik S I
出版信息
Genetika. 1987 Jan;23(1):63-70.
PMID:3469124
Abstract
It is possible to determine chromosomal position of the genes having definite genetic localization, using chiasmata distribution along the chromosome. This approach was used for subchromosomal mapping of the house mouse genes. It was shown that the chiasmata distributions are different for different chromosomes. The positions of some gene on chromosomes 1, 2, 17 and 19 were determined. The results coincide with those on subchromosomal gene mapping using chromosome translocations and in situ hybridization.
摘要
利用沿染色体的交叉分布来确定具有明确遗传定位的基因的染色体位置是可行的。这种方法被用于小家鼠基因的亚染色体定位。结果表明，不同染色体的交叉分布是不同的。确定了1号、2号、17号和19号染色体上一些基因的位置。这些结果与使用染色体易位和原位杂交进行亚染色体基因定位的结果一致。
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