LAMP3（CD208）在口腔鳞状细胞癌和上皮发育异常中的表达及预后不良的临床病理特征
LAMP3 (CD208) Expression in Squamous Cell Carcinoma and Epithelial Dysplasia of the Oral Cavity and Clinicopathological Characteristics of Unfavorable Prognosis.
作者信息
Shahabinejad Mehdi, Zare Reza, Asadi Zeynab, Mohajertehran Farnaz
机构信息
Department of Oral and Maxillofacial Pathology, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
Oral and Maxillofacial Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Rep Biochem Mol Biol. 2021 Jan;9(4):373-378. doi: 10.52547/rbmb.9.4.373.
BACKGROUND
This study aimed to evaluate LAMP3 gene expression in oral squamous cell carcinoma (OSCC) and dysplastic oral epithelium by quantitative real-time polymerase chain reaction (qPCR) and compare expression in different disease grades and stages.
METHODS
In this study, 60 OSCC and dysplastic oral epithelium samples were obtained from the Mashhad University of Medical Sciences together with their demographic and clinicopathological documents. LAMP3 expression was measured by qPCR.
RESULTS
expression was significantly greater in OSCC than in dysplasia samples (P=0.001), in grade III OSCC than in grades I and II, and also greater in advanced than in early OSCC disease stage (P=0.001).
CONCLUSION
The significantly greater expression in OSCC than in dysplastic epithelium indicates a role for in carcinogenesis in oral mucosa. Our results suggest may be useful as an anticancer target and/or to predict disease pathogenesis in OSCC patient's cells.
背景
本研究旨在通过定量实时聚合酶链反应（qPCR）评估LAMP3基因在口腔鳞状细胞癌（OSCC）和发育异常的口腔上皮中的表达，并比较其在不同疾病分级和分期中的表达情况。
方法
在本研究中，从马什哈德医科大学获取了60份OSCC和发育异常的口腔上皮样本及其人口统计学和临床病理资料。通过qPCR测量LAMP3的表达。
结果
OSCC中的表达明显高于发育异常样本（P = 0.001），III级OSCC中的表达高于I级和II级，晚期OSCC疾病阶段的表达也高于早期（P = 0.001）。
结论
OSCC中的表达明显高于发育异常的上皮，表明其在口腔黏膜致癌过程中发挥作用。我们的结果表明，它可能作为抗癌靶点和/或预测OSCC患者细胞中的疾病发病机制有用。
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