Hoseinkhani Zohreh, Rastegari-Pouyani Mohsen, Tajemiri Farahnaz, Yari Kheirollah, Mansouri Kamran
Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Student Research Committee, Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Rep Biochem Mol Biol. 2021 Jan;9(4):435-441. doi: 10.52547/rbmb.9.4.435.
The association of 1,25-dihydroxy vitamin D3 (1,25(OH)2D3) and its receptor, vitamin D receptor (VDR), with cancer types have been studied. However, there are controversial findings regarding the association of specific VDR polymorphisms with different kinds of cancers. In the current study, we investigated the association of VDR polymorphisms (Fok1 (rs2228570), (rs7975232), (rs1544410), and (rs731236)) with the risk of gastric cancer in a Kurdish population of Kermanshah in Iran for the first time.
In this case-control study, the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used in 99 gastric cancer patients and 100 healthy subjects as controls.
The frequencies of f (), b (), t (), and a () alleles were: 55.6%, 27.3%, 62.1%, and 44.95% in the patient group, respectively and 42%, 29.5%, 54.5%, and 46.0% in the control group, respectively. Analysis of the results indicated that there was a positive association between the frequency of genotypes with gastric cancer risk (= 0.021). However, no statistically significant association of , Taq1, and polymorphisms of VDR was detected in gastric patients when compared with healthy individuals.
VDR- polymorphism could increase the risk of GC development and predispose to the disease by mechanisms.
1,25 - 二羟基维生素D3（1,25(OH)2D3）及其受体维生素D受体（VDR）与癌症类型的关联已得到研究。然而，关于特定VDR多态性与不同类型癌症的关联存在有争议的研究结果。在本研究中，我们首次在伊朗克尔曼沙阿的库尔德人群中调查了VDR多态性（Fok1（rs2228570）、 （rs7975232）、 （rs1544410）和 （rs731236））与胃癌风险的关联。
在这项病例对照研究中，聚合酶链反应 - 限制性片段长度多态性（PCR - RFLP）方法被用于99例胃癌患者和100名健康受试者作为对照。
f（）、b（）、t（）和a（）等位基因的频率在患者组中分别为55.6%、27.3%、62.1%和44.95%，在对照组中分别为42%、29.5%、54.5%和46.0%。结果分析表明， 基因型频率与胃癌风险之间存在正相关（= 0.021）。然而，与健康个体相比，在胃癌患者中未检测到VDR的 、Taq1和 多态性具有统计学意义的关联。
VDR - 多态性可能通过某些机制增加胃癌发生风险并使个体易患该疾病。
