Department of Neurosurgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Science, The Third Affiliated Hospital of Shanxi Medical University, Taiyuan, China.
Department of Neurosurgery, Shanxi Corps Hospital of PAP, Taiyuan, China.
Folia Neuropathol. 2021;59(1):50-66. doi: 10.5114/fn.2021.105131.
More than 50 million people are affected by traumatic brain injury (TBI) each year around the world, and nearly half of the population worldwide will have one or more TBI(s) in their lifetime. And in 2017, more than 1.39 billion people in China suffered from TBI, representing nearly 18% of the world population; these were mainly caused by road traffic incidents. Salvianolic acid A is a compound obtained from Salvia miltiorrhiza Bunge, which is one of the active components of many traditional Chinese medicines for the treatment of cardiovascular and cerebrovascular disease, with the effect of inhibition of inflammatory response. ASC is a critical factor in the activation of inflammation response process via promoting the maturation of caspase-1, and activation of NLPR3 under bacterial infection promotes the necrosis of cells in an ASC-dependent manner. However, few studies focus on the effect of ASC in a TBI model. In this study, we found that inhibition of ASC reduced the expression of inflammatory cytokines, and the concentration of calcium and ROS, while it increased the expression of mitochondrial function-related proteins. We further noticed that these effects were regulated by DLK2/MLK3/JNK signalling pathway and might contribute to the treatment of TBI.
每年全世界有超过 5000 万人受到创伤性脑损伤（TBI）的影响，全世界近一半的人口在其一生中会经历一次或多次 TBI。2017 年，中国有超过 13.9 亿人患有 TBI，占世界人口的近 18%；这些主要是由道路交通事故事故造成的。丹酚酸 A 是从丹参中提取的一种化合物，是许多治疗心脑血管疾病的中药的有效成分之一，具有抑制炎症反应的作用。ASC 是通过促进半胱天冬酶-1 的成熟和 NLPR3 在细菌感染下的激活，从而在炎症反应过程中激活的关键因素，以 ASC 依赖性方式促进细胞坏死。然而，很少有研究关注 ASC 在 TBI 模型中的作用。在这项研究中，我们发现抑制 ASC 可降低炎症细胞因子的表达和钙和 ROS 的浓度，同时增加线粒体功能相关蛋白的表达。我们进一步注意到，这些作用是由 DLK2/MLK3/JNK 信号通路调节的，可能有助于 TBI 的治疗。
