Department of Neurosurgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.
Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China.
Front Immunol. 2024 Jul 30;15:1433590. doi: 10.3389/fimmu.2024.1433590. eCollection 2024.
Salvianolic acid A (SalA), a bioactive compound extracted from Salvia miltiorrhiza, has garnered considerable interest for its potential in ameliorating the post-stroke neuroinflammation. This review delineates the possible molecular underpinnings of anti-inflammatory and neuroprotective roles of SalA, offering a comprehensive analysis of its therapeutic efficacy in preclinical studies of ischemic stroke. We explore the intricate interplay between post-stroke neuroinflammation and the modulatory effects of SalA on pro-inflammatory cytokines, inflammatory signaling pathways, the peripheral immune cell infiltration through blood-brain barrier disruption, and endothelial cell function. The pharmacokinetic profiles of SalA in the context of stroke, characterized by enhanced cerebral penetration post-ischemia, makes it particularly suitable as a therapeutic agent. Preliminary clinical findings have demonstrated that salvianolic acids (SA) has a positive impact on cerebral perfusion and neurological deficits in stroke patients, warranting further investigation. This review emphasizes SalA as a potential anti-inflammatory agent for the advancement of innovative therapeutic approaches in the treatment of ischemic stroke.
丹酚酸 A（SalA）是从丹参中提取的一种生物活性化合物，因其在改善卒中后神经炎症方面的潜力而备受关注。本综述阐述了 SalA 抗炎和神经保护作用的可能分子基础，全面分析了其在缺血性卒中的临床前研究中的治疗效果。我们探讨了卒中后神经炎症与 SalA 对促炎细胞因子、炎症信号通路、通过血脑屏障破坏的外周免疫细胞浸润和内皮细胞功能的调节作用之间的复杂相互作用。SalA 在卒中情况下的药代动力学特征，表现为缺血后大脑穿透增强，使其特别适合作为治疗药物。初步临床研究结果表明，丹酚酸（SA）对卒中患者的脑灌注和神经功能缺损有积极影响，值得进一步研究。本综述强调了 SalA 作为一种潜在的抗炎药物，可用于缺血性卒中治疗的创新治疗方法的发展。
