手性氢化环状四取代烯烃脱氢氨基酸衍生物。
Enantioselective hydrogenation of cyclic tetrasubstituted-olefinic dehydroamino acid derivatives.
机构信息
State Key Laboratory of Bio-Organic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling Ling Road, Shanghai 200032, China.
School of Physical Science and Technology, ShanghaiTech University, Shanghai 200031, China.
出版信息
Chem Commun (Camb). 2021 Jun 3;57(45):5546-5549. doi: 10.1039/d1cc01277k.
An efficient asymmetric hydrogenation of cyclic tetrasubstituted-olefinic dehydroamino acid derivatives has been achieved with a Rh-ArcPhos catalyst, affording a series of α-acylamino-β-alkyl tetrahydropyranones with two contiguous chiral centers in up to 96% ee and 1000 TON.
一种高效的不对称氢化环状四取代烯烃脱氢氨基酸衍生物的方法已经通过 Rh-ArcPhos 催化剂实现，该方法可以提供一系列具有两个连续手性中心的 α-酰氨基-β-烷基四氢吡喃酮，ee 值高达 96%，TON 值高达 1000。
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