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鼻中隔偏曲伴变应性鼻炎患者行鼻中隔成形术联合双侧下鼻甲整形术改善鼻塞及主观症状的作用:一项介入性前瞻性研究。

Role of Bilateral Inferior Turbinoplasty as an Adjunct to Septoplasty in Improving Nasal Obstruction and Subjective Performance in Patients With Deviated Nasal Septum Associated With Allergic Rhinitis: An Interventional, Prospective Study.

机构信息

Department of Otorhinolaryngology and Head-Neck Surgery, Jagannath Gupta Institute of Medical Sciences and Hospital, Budge Budge, West Bengal, India.

Department of Otorhinolaryngology and Head-Neck Surgery, Medical College and Hospital, Kolkata, West Bengal, India.

出版信息

Ear Nose Throat J. 2023 Jul;102(7):445-452. doi: 10.1177/01455613211015440. Epub 2021 May 10.

Abstract

BACKGROUND

Patients with nasal obstruction due to deviated nasal septum (DNS) often have allergic rhinitis (AR) as contributing factor. When optimal medical therapy for AR fails, septoplasty alone may not adequately treat nasal obstruction. Therefore, with bilateral inferior turbinate hypertrophy representing long-standing AR, adding bilateral inferior turbinoplasty (BIT) to septoplasty might be beneficial.

OBJECTIVE

To assess whether septoplasty with/without BIT alleviates nasal obstruction in the above patient cohort and whether adding BIT to septoplasty brings significant benefit.

METHODOLOGY

In this interventional, prospective study, patients with nasal obstruction due to DNS and persistent, moderate-severe AR refractory to optimal medication were randomly allocated into group A (septoplasty alone) and group B (septoplasty with BIT). Nasal Obstruction and Symptom Evaluation (NOSE) score, along with Subjective Performance parameters (days-off/month; number of outdoor visits/month; overall satisfaction score [OSS]) were used to assess the symptom and quality of life, respectively, at follow-up.

RESULTS

Each group had 40 age/sex-matched patients. Friedman test, and subsequent pair-wise comparison without Bonferroni correction, revealed that septoplasty with/without BIT elicited significant reduction in NOSE scores and in the Subjective Performance parameters (days-off/month; number of outdoor visits/month) at 3 and 6 months. Wilcoxon Signed Rank test revealed that the OSS also improved significantly with time. Further, comparison revealed significant improvement in NOSE scores at all levels of follow-up when BIT was included. However, there were no significant differences in the Subjective Performance parameters at any level of follow-up. Improvement in OSS was significant only at 3 months but not subsequently.

CONCLUSION

Septoplasty with/without BIT is helpful in treating patients with DNS and refractory AR. However, although adding BIT brings significant benefit in decreasing nasal obstruction, it does not significantly improve the Subjective Performance parameters during follow-up, except for OSS at the third month.

摘要

背景

鼻中隔偏曲(DNS)导致的鼻塞患者常伴有变应性鼻炎(AR)。当 AR 的最佳药物治疗失败时,单纯鼻中隔矫正术可能无法充分治疗鼻塞。因此,对于双侧下鼻甲肥大伴长期 AR 的患者,鼻中隔矫正术联合双侧下鼻甲整形术(BIT)可能有益。

目的

评估鼻中隔矫正术联合/不联合 BIT 是否能缓解上述患者群体的鼻塞症状,以及联合 BIT 是否能带来显著获益。

方法

这是一项干预性、前瞻性研究,将鼻中隔偏曲伴持续性、中重度 AR 药物治疗抵抗的患者随机分为 A 组(单纯鼻中隔矫正术)和 B 组(鼻中隔矫正术联合 BIT)。采用鼻阻塞和症状评估(NOSE)评分和主观表现参数(每月休假天数;每月户外活动次数;总体满意度评分[OSS])评估症状和生活质量。

结果

每组各 40 例年龄/性别匹配的患者。弗里德曼检验和随后未经 Bonferroni 校正的两两比较显示,鼻中隔矫正术联合/不联合 BIT 可显著降低 NOSE 评分和主观表现参数(每月休假天数;每月户外活动次数),在 3 个月和 6 个月时观察到。Wilcoxon 符号秩检验显示,OSS 随时间也显著改善。进一步比较显示,当包括 BIT 时,在所有随访水平上,NOSE 评分均显著改善。然而,在任何随访水平上,主观表现参数均无显著差异。仅在 3 个月时,OSS 改善有显著意义,但随后无显著意义。

结论

鼻中隔矫正术联合/不联合 BIT 有助于治疗 DNS 和难治性 AR 患者。然而,尽管联合 BIT 在减轻鼻塞方面有显著获益,但除了 3 个月时的 OSS 外,在随访期间,BIT 对主观表现参数并无显著改善。

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