Otorhinolaryngology-Head and Neck Surgery Department, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy.
Otorhinolaryngology-Head and Neck Surgery Department, University Hospital of Modena, Italy.
Acta Otorhinolaryngol Ital. 2021 Jun;41(3):197-205. doi: 10.14639/0392-100X-N1436. Epub 2021 May 6.
Interactions between SARS-CoV-2 and pharyngeal associated lymphoid tissue are thought to influence the manifestations of COVID-19. We aimed to determine whether a previous history of tonsillectomy, as a surrogate indicator of a dysfunctional pharyngeal associated lymphoid tissue, could predict the presentation and course of COVID-19.
Multicentric cross-sectional observational study involving seven hospitals in Northern and Central Italy. Data on the clinical course and signs and symptoms of the infection were collected from 779 adults who tested positive for SARS-CoV-2, and analysed in relation to previous tonsillectomy, together with demographic and anamnestic data.
Patients with previous tonsillectomy showed a greater risk of fever, temperature higher than 39°C, chills and malaise. No significant differences in hospital admissions were found.
A previous history of tonsillectomy, as a surrogate indicator of immunological dysfunction of the pharyngeal associated lymphoid tissue, could predict a more intense systemic manifestation of COVID-19. These results could provide a simple clinical marker to discriminate suspected carriers and to delineate more precise prognostic models.
SARS-CoV-2 与咽相关淋巴组织之间的相互作用被认为会影响 COVID-19 的表现。我们旨在确定扁桃体切除术的既往史（作为咽相关淋巴组织功能障碍的替代指标）是否可以预测 COVID-19 的表现和病程。
这是一项涉及意大利北部和中部 7 家医院的多中心横断面观察性研究。从 779 名 SARS-CoV-2 检测呈阳性的成年人中收集了与感染相关的临床病程以及体征和症状的数据，并根据既往扁桃体切除术进行了分析，同时还收集了人口统计学和病史数据。
既往有扁桃体切除术的患者发热、体温高于 39°C、寒战和不适的风险更高。住院治疗方面无显著差异。
扁桃体切除术的既往史（作为咽相关淋巴组织免疫功能障碍的替代指标）可能预示着 COVID-19 更严重的全身表现。这些结果可以提供一个简单的临床标志物来区分疑似携带者，并描绘更精确的预后模型。
